2 documents found, page 1 of 1
Muscle-Bone Crosstalk in Chronic Kidney Disease: the Potential Modulatory Effec...
Leal, D; Ferreira, A; Watson, E; Wilund, K; Viana, JChronic kidney disease (CKD) is a prevalent worldwide public burden that increasingly compromises overall health as the disease progresses. Two of the most negatively affected tissues are bone and skeletal muscle, with CKD negatively impacting their structure, function and activity, impairing the quality of life of these patients and contributing to morbidity and mortality. Whereas skeletal health in this popul...
Mosquito-Derived Anophelin Sulfoproteins Are Potent Antithrombotics
Watson, E; Liu, X; Thompson, R; Ripoll-Rozada, J; Wu, M; Alwis, I; Gori, A; Loh, C; Parker, B; Otting, G; Jackson, S; Pereira, P; Payne, RThe anophelins are small protein thrombin inhibitors that are produced in the salivary glands of the Anopheles mosquito to fulfill a vital role in blood feeding. A bioinformatic analysis of anophelin sequences revealed the presence of conserved tyrosine residues in an acidic environment that were predicted to be post-translationally sulfated in vivo. To test this prediction, insect cell expression of two anophe...