3 documents found, page 1 of 1
Natural ergot alkaloids in ocular pharmacotherapy: known molecules for novel na...
Baldim, Iara; Oliveira, Wanderley P.; Kadian, Varsha; Rao, Rekha; Yadav, Nitesh; Mahant, Sheefali; Lucarini, Massimo; Durazzo, AlessandraSeveral pharmacological properties are attributed to ergot alkaloids as a result of their antibacterial, antiproliferative, and antioxidant effects. Although known for their biomedical applications (e.g., for the treatment of glaucoma), most ergot alkaloids exhibit high toxicological risk and may even be lethal to humans and animals. Their pharmacological profile results from the structural similarity between l...
Ocular cell lines and genotoxicity assessment
Souto, Eliana B.; Campos, Joana R.; Da Ana, Raquel; Martins-Gomes, Carlos; Silva, Améia M.; Souto, Selma B.; Lucarini, Massimo; Durazzo, AlessandraGenotoxicity screening tests aim to evaluate if and to what extent a compound in contact with the human body (e.g., a drug molecule, a compound from the environment) interacts with DNA. The comet assay is a sensitive method used to predict the risk of DNA damage in individual cells, as it quantifies the tape breaks, being the alkaline version (pH > 13) the most commonly used in the laboratory. Epithelial cells ...
Diabetic retinopathy and ocular melanoma: how far we are?
Souto, Eliana B.; Campos, Joana R.; Da Ana, Raquel; Fangueiro, Joana F.; Martins-Gomes, Carlos; Durazzo, Alessandra; Lucarini, MassimoDiabetic retinopathy causes vascular damage to retinal neurons, presenting characteristics of chronic inflammation. The development of new therapies capable of combating vision loss involves knowledge of inflammatory retinal changes. Studies in animal models and patients with diabetes have shown a high expression of the inflammatory molecules that are involved in the progression of diabetic retinopathy. Uveal m...