6 documents found, page 1 of 1
Characterization of the striatal extracellular matrix in a mouse model of Parki...
Freitas, A; Aroso, M; Barros, A; Fernández, M; Conde-Sousa, E; Leite, M; Carvalho, ED; Ribeiro, CC; Ferreira, R; Pêgo, AP; Vitorino, R; Gomez-Lazaro, MParkinson’s disease’s etiology is unknown, although evidence suggests the involvement of oxidative modifications of intracellular components in disease pathobiology. Despite the known involvement of the extracellular matrix in physiology and disease, the influence of oxidative stress on the matrix has been neglected. The chemical modifications that might accumulate in matrix components due to their long half-li...
4specid: Reference dna libraries auditing and annotation system for forensic ap...
Neto, L; Pinto, N; Proença, A; Amorim, A; Conde-Sousa, EForensic genetics is a fast-growing field that frequently requires DNA-based taxonomy, namely, when evidence are parts of specimens, often highly processed in food, potions, or ointments. Reference DNA-sequences libraries, such as BOLD or GenBank, are imperative tools for taxonomic assignment, particularly when morphology is inadequate for classification. The auditing and cura- tion of these datasets require re...
Detection of HER2 from Haematoxylin-Eosin slides through a cascade of deep lear...
Barbera, DL; Polónia, A; Roitero, K; Conde-Sousa, E; Mea, VDBreast cancer is the most frequently diagnosed cancer in woman. The correct identification of the HER2 receptor is a matter of major importance when dealing with breast cancer: an over-expression of HER2 is associated with aggressive clinical behaviour; moreover, HER2 targeted therapy results in a significant improvement in the overall survival rate. In this work, we employ a pipeline based on a cascade of deep...
Engineering Hydrogels with Affinity-Bound Laminin as 3D Neural Stem Cell Cultur...
Barros, D; Conde-Sousa, E; Gonçalves, AM; Han, WM; García, AJ; Amaral, IF; Pêgo, APLaminin incorporation into biological or synthetic hydrogels has been explored to recapitulate the dynamic nature and biological complexity of neural stem cell (NSC) niches. However, the strategies currently explored for laminin immobilization within three-dimensional (3D) matrices do not address a critical aspect influencing cell-matrix interactions, which is the control over laminin conformation and orientati...
An affinity-based approach to engineer laminin-presenting cell instructive micr...
Barros, D; Parreira, P; Furtado, J; Ferreira-da-Silva, F; Conde-Sousa, E; García, A; Martins, MCL; Amaral, IF; Pêgo, APLaminin immobilization into diverse biological and synthetic matrices has been explored to replicate the microenvironment of stem cell niches and gain insight into the role of extracellular matrix (ECM) on stem cell behavior. However, the site-specific immobilization of this heterotrimeric glycoprotein and, consequently, control over its orientation and bioactivity has been a challenge that has limited many of ...
A dispersal of Homo sapiens from southern to eastern Africa immediately precede...
Rito, T; Vieira, D; Silva, M; Conde-Sousa, E; Pereira, L; Mellars, P; Richards, MB; Soares, PAfrica was the birth-place of Homo sapiens and has the earliest evidence for symbolic behaviour and complex technologies. The best-attested early flowering of these distinctive features was in a glacial refuge zone on the southern coast 100–70 ka, with fewer indications in eastern Africa until after 70 ka. Yet it was eastern Africa, not the south, that witnessed the first major demographic expansion, ~70–60 ka,...