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About the necessity of including HoBi-like pestiviruses in bovine respiratory a...
Silva,Paulo Henrique Hümmelgen; Weiblen,Rudi; Flores,Eduardo F.ABSTRACT: HoBi-like pestiviruses (HoBiPeV) constitute a novel group of bovine pestiviruses, genetically and antigenically related to bovine viral diarrhea virus 1 (BVDV-1) and BVDV-2. Recent data shows that HoBiPeV are endemic among Brazilian cattle, yet bovine reproductive/respiratory vaccines contain only BVDV-1 and BVDV-2 strains. The present study investigated the neutralizing antibody response against thes...
Pathogenesis of Bovine alphaherpesvirus 2 in calves following different routes ...
Amaral,Bruna P.; Jardim,José C.; Cargnelutti,Juliana F.; Martins,Mathias; Weiblen,Rudi; Flores,Eduardo F.ABSTRACT: Bovine alphaherpesvirus 2 (BoHV-2) is the agent of herpetic mammilitis (BHM), a cutaneous and self-limiting disease affecting the udder and teats of cows. The pathogenesis of BoHV-2 is pourly understood, hampering the development of therapeutic drugs, vaccines and other control measures. This study investigated the pathogenesis of BoHV-2 in calves after inoculation through different routes. Three- to ...
Identification and characterization of pestiviruses isolated from individual fe...
Merchioratto,Ingryd; Monteiro,Francielle L.; Traesel,Carolina K.; Flores,Eduardo F.; Weiblen,Rudi; Brum,Mário C.S.ABSTRACT: The identification of diversity of bovine pestiviruses circulating in the field is fundamental for continuous evaluation of diagnostic tests and vaccine composition. In this article we performed the genetic and antigenic characterization of twelve bovine pestiviruses isolated in the western region of Rio Grande do Sul, Brazil. The viruses were isolated from sera of bovine fetuses or from animals with ...
Co-infection by Neopora caninum and bovine viral diarrhea virus in cattle from ...
Alves,Marta E.M.; Fernandes,Fagner D’ambroso; Monteiro,Francielle L.; Braunig,Patricia; Cargnelutti,Juliana F.; Flores,Eduardo F.; Weiblen,RudiABSTRACT: Reproductive tests in cattle are of great economic importance, given the impact it can have on the production system and may be caused by agents. Neospora caninum and Bovine Viral Diarrhea virus (BVDV) are considered of great importance as reproductive and should be considered responsible for keeping animals persistently infected. The present study included 479 calf serum samples for export in the sta...
Ganciclovir attenuates the respiratory disease induced by Equid alphaherpesviru...
Mortari,Ana Paula G.; Amaral,Bruna P.; Oliveira,Pablo S.B. De; Dotto,Evelyn K.; Flores,Mariana M.; Cargnelutti,Juliana F.; Weiblen,RudiABSTRACT: Equid alphaherpesvirus 1 (EHV-1) is an important pathogen of horses, associated with respiratory, neurological disease and abortions. As vaccination is not always effective, anti-herpetic therapy may represent an alternative to prevent the losses caused by the infection. We herein investigated the activity of ganciclovir (GCV), an anti-herpetic human drug, in rabbits experimentally infected with EHV-1...
In vitro activity of six antiviral drugs against equid alphaherpesvirus type 1 ...
Oliveira,Amanda Lovato de; Cargnelutti,Juliana Felipetto; Mortari,Ana Paula Gnocato; Flores,Eduardo Furtado; Weiblen,RudiABSTRACT: Equid alphaherpesvirus type 1 (EHV-1) is distributed worldwide and is a major agent of abortion, respiratory and neurological disease in horses. No specific treatment is available for EHV-1 infection, yet the potential of antiviral therapy has been explored. In this study we investigated the in vitro activity of Acyclovir, Ganciclovir, Foscarnet, Famciclovir, Vidarabina and Cidofovir against EHV-1. Fo...
Epidemiological, clinical and pathological features of canine parvovirus 2c inf...
Oliveira,Pablo S.B. de; Cargnelutti,Juliana F.; Masuda,Eduardo K.; Fighera,Rafael A.; Kommers,Glaucia D.; Silva,Marcia C. da; Weiblen,RudiABSTRACT: Canine parvovirus type 2c (CPV-2c) emerged in Europe in the early 2000’s and rapidly spread out worldwide. Clinical and molecular data have demonstrated its circulation in Brazilian dogs, yet detailed descriptions of cases are still lacking. This article describes the epidemiological, clinical and pathological features of 24 cases of CPV-2c-associated disease in dogs submitted to veterinary clinics an...
Detection and genetic identification of pestiviruses in Brazilian lots of fetal...
Monteiro,Francielle L.; Cargnelutti,Juliana F.; Braunig,Patrícia; Folgueras-Flatschart,Aurea V.; Santos,Nathália C.; Pituco,Edviges M.; Weiblen,RudiABSTRACT: The present study performed a genetic identification of pestiviruses contaminating batches of fetal bovine serum (FBS) produced in Brazil from 2006 to 2014. Seventy-three FBS lots were screened by a RT-PCR targeting the 5’untranslated region (UTR) of the pestivirus genome. Thirty-nine lots (53.4%) were positive for pestivirus RNA and one contained infectious virus. Nucleotide sequencing and phylogenet...
Serological response to rabies virus induced by commercial vaccines in cattle
Martins,Mathias; Quadros,João Motta de; Flores,Eduardo Furtado; Weiblen,RudiABSTRACT: The antibody response to rabies virus (RABV) induced by commercial vaccines in heifers was investigated. For this, 84 heifers were vaccinated twice (30 days interval) with each of four vaccines (G1 = 14 animals; G2 = 24; G3 = 22 and G4 = 24) and received a booster vaccination 360 days later. Serum samples collected at different intervals after vaccination and 30 days after booster were submitted to a ...
Antibodies against rabies virus in dogs with and without history of vaccination...
Fernandes,Karina Gonzalez; Martins,Mathias; Amaral,Bruna Portolan; Cargnelutti,Juliana Felipetto; Weiblen,Rudi; Flores,Eduardo FurtadoABSTRACT: The present study investigated the frequency and magnitude of neutralizing antibodies to rabies virus (RABV) in dogs with and without historic of vaccination in Santa Maria/RS. Group A included serum samples from 440 dogs with recent historic of vaccination against rabies, obtained during the 2015 rabies vaccination campaign. Group B included 300 serum samples from dogs submitted to the Veterinary Hos...