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Lozza, Laura; Moura-Alves, Pedro; Domaszewska, Teresa; Crespo, Carolina Lage; Streata, Ioana; Kreuchwig, Annika; Puyskens, Andreas; Bechtle, Marina

Publisher Copyright: © 2020, The Author(s).; An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Date: 2020   |   Origin: Repositório Institucional da UNL
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The Henna pigment Lawsone activates the Aryl Hydrocarbon Receptor and impacts s...

Lozza, Laura; Moura-Alves, Pedro; Domaszewska, Teresa; Lage Crespo, Carolina; Streata, Ioana; Kreuchwig, Annika; Puyskens, Andreas; Bechtle, Marina

As a first host barrier, the skin is constantly exposed to environmental insults that perturb its integrity. Tight regulation of skin homeostasis is largely controlled by the aryl hydrocarbon receptor (AhR). Here, we demonstrate that Henna and its major pigment, the naphthoquinone Lawsone activate AhR, both in vitro and in vivo. In human keratinocytes and epidermis equivalents, Lawsone exposure enhances the pro...

Date: 2019   |   Origin: Repositório Institucional da UNL
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