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Role of endoscopic biopsies and morphologic features in predicting microsatelli...

Silva, João R.; Mascarenhas-Lemos, Luís; Neto do Nascimento, Catarina; Sousa Marques, Diogo; Wen, Xiaogang; Pinho, Lídia; Maio, Rui; Pontes, Patrícia

Evaluation of mismatch repair (MMR) protein and microsatellite instability (MSI) status plays a pivotal role in the management of gastric cancer (GC) patients. In this study, we aimed to evaluate the accuracy of gastric endoscopic biopsies (EBs) in predicting MMR/MSI status and to uncover histopathologic features associated with MSI. A multicentric series of 140 GCs was collected retrospectively, in which EB an...


EBV and MSI status in gastric cancer: does it matter?

Nascimento, Catarina Neto do; Mascarenhas-Lemos, Luís; Silva, João Ricardo; Marques, Diogo Sousa; Gouveia, Catarina Ferreira; Faria, Ana; Velho, Sónia

We investigated the impactof microsatellite instability (MSI) and Epstein–Barr virus (EBV) status in gastric cancer (GC), regarding response to perioperative chemotherapy (POPChT), overall survival (OS), and progression-free survival (PFS). We included 137 cases of operated GC, 51 of which were submitted to POPChT. MSI status was determined by multiplex PCR and EBV status by EBV-encoded RNA in situ hybridizatio...


EBV and MSI status in gastric cancer: does it matter?

do Nascimento, Catarina Neto; Mascarenhas-Lemos, Luís; Silva, João Ricardo; Marques, Diogo Sousa; Gouveia, Catarina Ferreira; Faria, Ana; Velho, Sónia

We investigated the impactof microsatellite instability (MSI) and Epstein-Barr virus (EBV) status in gastric cancer (GC), regarding response to perioperative chemotherapy (POPChT), overall survival (OS), and progression-free survival (PFS). We included 137 cases of operated GC, 51 of which were submitted to POPChT. MSI status was determined by multiplex PCR and EBV status by EBV-encoded RNA in situ hybridizatio...


STEWART-TREVES SYNDROME – A RARE COMPLICATION OF A COMMON FINDING

Massa, António Fernandes; Guedes, Rita; Ferreira, Eduarda Osório; Wen, Xiaogang; Baptista, Armando

Stewart-Treves syndrome is a rare entity with bad prognosis. It has been described as a lymphangiosarcoma in lymphedema context. We present the case of a 79-year-old female patient with a history of left breast invasive ductal carcinoma 10 years ago, treated with mastectomy and axillary lymph node dissection, chemotherapy and radiotherapy. She was observed in the Dermatology department for cutaneous changes in ...


Helicobacter pylori colonization of the adenotonsillar tissue: fact or fiction?

Vilarinho, Sérgio; Guimarães, N.; Ferreira, Rui M.; Gomes, Bárbara; Wen, Xiaogang; Vieira, M. J.; Carneiro, Fátima; Godinho, Tiago; Figueiredo, C.

Objective: The transmission of the gastric pathogen Helicobacter pylori involves the oral route. Molecular techniques have allowed the detection of H. pylori DNA in samples of the oral cavity, although culture of H. pylori from these type of samples has been sporadic. Studies have tried to demonstrate the presence of H. pylori in adenotonsillar tissue, with contradictory results. Our aim was to clarify whether ...


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