4 documents found, page 1 of 1
Differential Protein and Glycan Packaging into Extracellular Vesicles in Respon...
Martins, ÁM; Lopes, TM; Diniz, F; Pires, J; Osorio, H; Pinto, F; Freitas, D; Reis, CAAlterations of the glycosylation machinery are common events in cancer, leading to the synthesis of aberrant glycan structures by tumor cells. Extracellular vesicles (EVs) play a modulatory role in cancer communication and progression, and interestingly, several tumor-associated glycans have already been identified in cancer EVs. Nevertheless, the impact of 3D tumor architecture in the selective packaging of ce...
Analysis of the effect of increased a2,3-sialylation on RTK activation in MKN45...
Balmaña, M; Diniz, F; Feijão, T; Barrias, CC; Mereiter, S; Reis, CAIn the scenario of personalized medicine, targeted therapies are currently the focus of cancer drug development. These drugs can block the growth and spread of tumor cells by interfering with key molecules involved in malignancy, such as receptor tyrosine kinases (RTKs). MET and Recepteur d’Origine Nantais (RON), which are RTKs frequently overactivated in gastric cancer, are glycoprotein receptors whose activat...
Multicellular Human Gastric Cancer Spheroids Mimic the Glycosylation Phenotype ...
Balmaña, M; Mereiter, S; Diniz, F; Feijão, T; Barrias, CC; Reis, CACellular glycosylation plays a pivotal role in several molecular mechanisms controlling cell⁻cell recognition, communication, and adhesion. Thus, aberrant glycosylation has a major impact on the acquisition of malignant features in the tumor progression of patients. To mimic these in vivo features, an innovative high-throughput 3D spheroid culture methodology has been developed for gastric cancer cells. The ass...
Application of a Dot Blot Hybridization Platform to Assess Streptococcus uberis...
Albuquerque, P; Ribeiro, NJ; Almeida, A; Panschin, I; Porfirio, A; Vales, M; Diniz, F; Madeira, H; Tavares, FStreptococcus uberis is considered one of the most important pathogens associated with bovine mastitis. While traditionally acknowledged as an environmental pathogen, S. uberis has been shown to adopt a contagious epidemiological pattern in several dairy herds. Since different control strategies are employed depending on the mode of transmission, in-depth studies of S. uberis populations are essential to determ...