11 documents found, page 1 of 2
Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Weste...
Amorim, Ricardo; Simões, Inês C. M.; Teixeira, José; Cagide, Fernando; Potes, Yaiza; Soares, Pedro; Carvalho, Adriana; Tavares, Ludgero C.Non-alcoholic fatty liver disease (NAFLD) is a health concern affecting 24% of the population worldwide. Although the pathophysiologic mechanisms underlying disease are not fully clarified, mitochondrial dysfunction and oxidative stress are key players in disease progression. Consequently, efforts to develop more efficient pharmacologic strategies targeting mitochondria for NAFLD prevention/treatment are underw...
Mitochondria, oxidative stress and nonalcoholic fatty liver disease: A complex ...
Karkucinska-Wieckowska, Agnieszka; Simoes, Ines C M; Kalinowski, Piotr; Lebiedzinska-Arciszewska, Magdalena; Zieniewicz, Krzysztof; Milkiewicz, PiotrAccording to the 'multiple-hit' hypothesis, several factors can act simultaneously in nonalcoholic fatty liver disease (NAFLD) progression. Increased nitro-oxidative (nitroso-oxidative) stress may be considered one of the main contributors involved in the development and risk of NAFLD progression to nonalcoholic steatohepatitis (NASH) characterized by inflammation and fibrosis. Moreover, it has been repeatedly ...
The Alterations of Mitochondrial Function during NAFLD Progression-An Independe...
Simões, Inês C M; Amorim, Ricardo; Teixeira, José; Karkucinska-Wieckowska, Agnieszka; Carvalho, Adriana; Pereira, Susana P; Simões, Rui F.The progression of non-alcoholic fatty liver (NAFL) into non-alcoholic steatohepatitis implicates multiple mechanisms, chief of which is mitochondrial dysfunction. However, the sequence of events underlying mitochondrial failure are still poorly clarified. In this work, male C57BL/6J mice were fed with a high-fat plus high-sucrose diet for 16, 20, 22, and 24 weeks to induce NAFL. Up to the 20th week, an early m...
Exploratory Data Analysis of Cell and Mitochondrial High-Fat, High-Sugar Toxici...
Amorim, Ricardo; Simões, Inês C. M.; Veloso, Caroline; Carvalho, Adriana; Simões, Rui F.; Pereira, Francisco B.; Thiel, Theresa; Normann, AndreaNon-alcoholic steatohepatitis (NASH), one of the deleterious stages of non-alcoholic fatty liver disease, remains a significant cause of liver-related morbidity and mortality worldwide. In the current work, we used an exploratory data analysis to investigate time-dependent cellular and mitochondrial effects of different supra-physiological fatty acids (FA) overload strategies, in the presence or absence of fruc...
The mystery of mitochondria-ER contact sites in physiology and pathology: A can...
Simoes, Ines C M; Morciano, Giampaolo; Lebiedzinska-Arciszewska, Magdalena; Aguiari, Gianluca; Pinton, Paolo; Potes, Yaiza; Wieckowski, Mariusz R.Mitochondria-associated membranes (MAM), physical platforms that enable communication between mitochondria and the endoplasmic reticulum (ER), are enriched with many proteins and enzymes involved in several crucial cellular processes, such as calcium (Ca2+) homeostasis, lipid synthesis and trafficking, autophagy and reactive oxygen species (ROS) production. Accumulating studies indicate that tumor suppressors a...
The role of mitochondria-associated membranes in cellular homeostasis and diseases
Perrone, Mariasole; Caroccia, Natascia; Genovese, Ilaria; Missiroli, Sonia; Modesti, Lorenzo; Pedriali, Gaia; Vezzani, BiancaMitochondria and endoplasmic reticulum (ER) are fundamental in the control of cell physiology regulating several signal transduction pathways. They continuously communicate exchanging messages in their contact sites called MAMs (mitochondria-associated membranes). MAMs are specific microdomains acting as a platform for the sorting of vital and dangerous signals. In recent years increasing evidence reported that...
Western Diet Causes Obesity-Induced Nonalcoholic Fatty Liver Disease Developmen...
Simoes, Ines C M; Karkucinska-Wieckowska, Agnieszka; Janikiewicz, Justyna; Szymanska, Sylwia; Pronicki, Maciej; Dobrzyn, Pawel; Dabrowski, MichalNonalcoholic fatty liver disease (NAFLD) is characterized by the development of steatosis, which can ultimately compromise liver function. Mitochondria are key players in obesity-induced metabolic disorders; however, the distinct role of hypercaloric diet constituents in hepatic cellular oxidative stress and metabolism is unknown. Male mice were fed either a high-fat (HF) diet, a high-sucrose (HS) diet or a com...
Targeting mitochondria to oppose the progression of nonalcoholic fatty liver di...
Grattagliano, Ignazio; Montezinho, Liliana P.; Oliveira, Paulo J.; Frühbeck, Gema; Gómez-Ambrosi, Javier; Montecucco, Fabrizio; Carbone, FedericoNonalcoholic fatty liver disease (NAFLD) is a condition characterized by the excessive accumulation of triglycerides in hepatocytes. NAFLD is the most frequent chronic liver disease in developed countries, and is often associated with metabolic disorders such as obesity and type 2 diabetes. NAFLD definition encompasses a spectrum of chronic liver abnormalities, ranging from simple steatosis (NAFL), to steatohep...
Regulation of PKCβ levels and autophagy by PML is essential for high-glucose-de...
Morganti, Claudia; Missiroli, Sonia; Lebiedzinska-Arciszewska, Magdalena; Ferroni, Letizia; Morganti, Lucia; Perrone, Mariasole; Ramaccini, DanielaObesity is a complex disease characterized by the accumulation of excess body fat, which is caused by an increase in adipose cell size and number. The major source of adipocytes comes from mesenchymal stem cells (MSCs), although their roles in obesity remain unclear. An understanding of the mechanisms, regulation, and outcomes of adipogenesis is crucial for the development of new treatments for obesity-related ...
Early Cardiac Mitochondrial Molecular and Functional Responses to Acute Anthrac...
Pereira, Gonçalo Castro; Pereira, Susana P.; Pereira, Francisco B.; Lourenço, Nuno António Marques; Lumini, José A; Pereira, Cláudia V.; Bjork, James A.Doxorubicin (DOX) is an anticancer drug widely used to treat human and nonhuman tumors but the late and persistent cardio-toxicity reduces the therapeutic utility of the drug. The full mechanism(s) of DOX-induced acute, subchronic and delayed toxicity, which has a preponderant mitochondrial component, remains unclear; therefore, it is clinically relevant to identify early markers to identify patients who are pr...