5 documents found, page 1 of 1
Dextrorotatory Chromomycins from the Marine Streptomyces sp. Associated to Paly...
Pinto,Francisco C. L.; Silveira,Edilberto R.; Vasconcelos,Ana Caroline L.; Florêncio,Katharine G. D.; Oliveira,Francisca A. S.; Sahm,Bianca B.A Streptomyces sp. (BRA-384) was selected among nine strains of bacteria isolated from the zoanthids Palythoa caribaeorum due to the high cytotoxic activity presented by its EtOAc extract (inhibitory concentration mean (IC50) of 2 ng mL-1) against colon cancer cell line. From the EtOAc extract of BRA-384 three new chemical entities (A6, A7 and A8) and one dextrorotatory chromomycin (A5), a promising class of an...
New Antiproliferative Polyunsaturated Epoxy-Heneicosane Derivatives Isolated fr...
Ávila,Fábio N.; Pinto,Francisco C. L.; Carneiro,Pedro B. M.; Ferreira,Kayanny Q.; Wilke,Diego V.; Nogueira,Nádia A. P.; Silveira,Edilberto R.Two new polyunsaturated 3,4-epoxy-heneicosane derivatives named as epoxy-lobophorene A and epoxy-lobophorene B were isolated from the brown alga Lobophora variegata, in addition to nine known compounds. The structures of the new compounds were elucidated using a combination of 1D/2D nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry (HRMS). The isolated compounds were submitted ...
Bioprospecting Anticancer Compounds from the Marine-Derived Actinobacteria Acti...
Silva,Amaro E. T.; Guimarães,Larissa A.; Ferreira,Elthon G.; Torres,Maria da Conceição M.; Silva,Alison B. da; Branco,Paola C.The actinomycete strain BRA 177 was recovered from sediment samples collected at the St. Peter and St. Paul Archipelago, Brazil. This work accessed the ability of this strain, identified as Actinomadura sp., to produce bioactive metabolites by exploring the genome and characterizing chemistry and cytotoxicity of isolated compounds. From the crude ethyl acetate extract, the pigments nonylprodigiosin, cyclononylp...
Steroids from the Brazilian Zoanthids Palythoa caribaeorum and Palythoa variabilis
Pinto,Francisco C. L.; Almeida,José Gustavo L.; Silveira,Edilberto R.; Costa,Arinice M.; Guimarães,Larissa A.; Wilke,Diego V.; Costa-Lotufo,Letícia V.Two unreported ergostane-type sterols 24(R)-7α-hydroperoxy-ergost-5-en-3β-ol and 6β-carboxyl-24(R)-(8→6)-abeo-ergostan-3β,5β-diol, along with seven known ones were isolated from the hexane and alcohol extracts from the zoanthids Palythoa caribaeorum and Palythoa variabilis. The structures of the new compounds were determined using spectroscopic techniques, including 1D and 2D nuclear magnetic resonance (NMR), h...
Perezone, from the gorgonian Pseudopterogorgia rigida, induces oxidative stress...
Abreu,Paula A.; Wilke,Diego V.; Araujo,Ana J.; Marinho-Filho,José Delano B.; Ferreira,Elthon G.; Ribeiro,Carlos Margo R.; Pinheiro,Leandro S.Abstract Four bisabolanes 1–4, including perezone (1) and triacetyl perezone (2), were isolated through a bioassay-guided fractionation of the extract obtained from the Caribbean gorgonian coral Pseudopterogorgia rigida collected during an expedition cruise to the Bahamas. All isolated compounds showed to be cytotoxic toward panel of four human tumor cell lines, as quantified by the MTT assay after 72 h incubat...