4 documents found, page 1 of 1
The influence of genetic stability on Aspergillus fumigatus virulence and azole...
Reis, Thaila Fernanda dos; Silva, Lilian Pereira; Castro, Patrícia Alves; Lima, Pollyne Borborema Almeida de; Carmo, Rafaela Andrade doGenetic stability is extremely important for the survival of every living organism, and a very complex set of genes has evolved to cope with DNA repair upon DNA damage. Here, we investigated the Aspergillus fumigatus AtmA (Ataxia-telangiectasia mutated, ATM) and AtrA kinases, and how they impact virulence and the evolution of azole resistance. We demonstrated that A. fumigatus atmA and atrA null mutants are hap...
Novel homologous lactate transporter improves l‑lactic acid production from gly...
Lima, Pollyne Borborema Almeida de; Mulder, Kelly Cristina Leite; Melo, Nadiele Tamires Moreira; Carvalho, Lucas Silva; Menino, Gisele SoaresBackground: Crude glycerol is the main byproduct of the biodiesel industry. Although it can have different applications, its purification is costly. Therefore, in this study a biotechnological route has been proposed for further utilization of crude glycerol in the fermentative production of lactic acid. This acid is largely utilized in food, pharmaceutical, textile, and chemical industries, making it the hydro...
Functional characterization of a xylose transporter in Aspergillus nidulans
Rodrigues, Fernando José dos Santos; Menino, João F.; Colabardini, Ana Cristina; Ries, Laure Nicolas Annick; Brown, Neil AndrewBACKGROUND: The production of bioethanol from lignocellulosic feedstocks will only become economically feasible when the majority of cellulosic and hemicellulosic biopolymers can be efficiently converted into bioethanol. The main component of cellulose is glucose, whereas hemicelluloses mainly consist of pentose sugars such as D-xylose and L-arabinose. The genomes of filamentous fungi such as A. nidulans encode...
Identification of glucose transporters in Aspergillus nidulans
Reis, Thaila Fernanda dos; Menino, João F.; Pedro Bom, Vinícius Leite; Brown, Neil Andrew; Colabardini, Ana Cristina; Savoldi, Marcelao characterize the mechanisms involved in glucose transport, in the filamentous fungus Aspergillus nidulans, we have identified four glucose transporter encoding genes hxtB-E. We evaluated the ability of hxtB-E to functionally complement the Saccharomyces cerevisiae EBY.VW4000 strain that is unable to grow on glucose, fructose, mannose or galactose as single carbon source. In S. cerevisiae HxtB-E were targeted ...