4 documents found, page 1 of 1
Optimized in-solution enrichment over a million ancient human SNPs
Davidson, Roberta; Roca-Rada, Xavier; Ravinshakar, Shyamsundar; Taufik, Leonard; Haarkötter, Christian; Collen, Evelyn; Williams, Matthew P.Background In-solution hybridization enrichment of genetic markers is a method of choice in paleogenomic studies, where the DNA of interest is generally heavily fragmented and contaminated with environmental DNA, and where the retrieval of genetic data comparable between individuals is challenging. Here, we benchmark the commercial “Twist Ancient DNA” reagent from Twist Biosciences using sequencing libraries fr...
The genetic history of Portugal over the past 5,000 years.
Roca-Rada, Xavier; Davidson, Roberta; Williams, Matthew P.; Villalba-Mouco, Vanessa; Carvalho, António Manuel Faustino de; Ravishankar, ShyamsundarRecent ancient DNA studies uncovering large-scale demographic events in Iberia have presented very limited data for Portugal, a country located at the westernmost edge of continental Eurasia. Here, we present the most comprehensive collection of Portuguese ancient genome-wide data, from 67 individuals spanning 5000 years of human history, from the Neolithic to the nineteenth century. We identify early admixture...
A 1000-year-old case of Klinefelter's syndrome diagnosed by integrating morphol...
Roca-Rada, Xavier; Tereso, Sofia; Rohrlach, Adam B.; Brito, André; Williams, Matthew P.; Umbelino, Cláudia .; Curate, Francisco T.; Deveson, Ira W.We thank the Municipality of Bragança, the University of Coimbra, the University of Adelaide, the Max Planck Society, and the Calouste Gulbenkian Foundation for the support provided. ST is supported by the Fundação para a Ciência e a Tecnologia (SFRH/BD/116363/2016). BL (FT170100448) and JCT (DE210101235) are supported by the Australian Research Council. ABR is supported by the European Research Council (771234...
A 1000-year-old case of Klinefelter's syndrome diagnosed by integrating morphol...
Roca-Rada, Xavier; Tereso, Sofia; Rohrlach, Adam B.; Brito, Andre; Williams, Matthew P.; Umbelino, Cláudia; Curate, Francisco; Deveson, Ira W.The skeleton of a human being buried over 1000 years ago, in the medieval archaeological site of Torre Velha, in north-eastern Portugal, was referred to us for analysis and investigation