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Improving the solubility of the antichagasic drug benznidazole through formatio...
Sobrinho,José Lamartine Soares; Soares,Mônica Felts de La Roca; Labandeira,Juan Jose Torres; Alves,Lariza Darlene Santos; Rolim Neto,Pedro JoséThis study describes unpublished research on improving the solubility of benznidazole by the formation of an inclusion complex. The cyclodextrins selected were αCD, βCD, γCD, HPβCD, RMβCD and SBβCD. All complexes were obtained in solution, presenting 1:1 stoichiometry according to the phase solubility diagram. The highest association constants were obtained with RMβCD and SBβCD, being selected for attainment of...
Date: 2011
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Origin: Oasisbr