Background: The introduction of anti-programmed cell death protein 1 (PD-1) immunotherapy has revolutionized the treatment landscape for melanoma, enhancing both response rates and survival outcomes in patients with advanced stages of the disease. Despite these remarkable advances, a noteworthy subset of patients (40%-60%) does not derive advantage from this therapeutic approach. This study aims to identify key...
Background: Vitamin D deficiency is common in older adults and has been linked with frailty and obesity, but it remains to be studied whether frail obese older adults are at higher risk of vitamin D deficiency. Therefore, the aim of this study is to explore the association between frailty, obesity indices and serum 25(OH)D concentrations. Methods: 1447 individuals with 65 years or older, participating in a cros...
Este estudo consiste na análise da influência que o espaço exerce na tomada de decisões quando o subconsciente do ser humano está no estado mais “ausente” do corpo, como por exemplo, ao fazer jogging. A investigação realizada teve como caso de estudo o Estádio Universitário de Lisboa (EUL). Este espaço conta com um número de praticantes de jogging cada vez maior e os seus percursos, que foram essencialmente cri...
Prototype validation is a major concern in modern electronic product design and development. Simulation, structural test, functional and timing debug are all forming parts of the validation process, although very often addressed as dissociated tasks. In this paper we describe an integrated approach to board-level prototype validation, based on a set of mandatory/optional BST instructions and a built-in controll...