8 documents found, page 1 of 1
Thresholds in deep-seabed mining: a primer for their development
Hitchin, B.; Smith, S.; Kröger, K.; Jones, DOB; Jaeckel, A.; Mestre, Nélia; Ardron, J.; Escobar, E.; van der Grient, J.; Amaro, T.The establishment of thresholds is integral to environmental management. This paper introduces the use of thresholds in the context of deep-seabed mining, a nascent industry for which an exploitation regime of regu-lations, standards and guidelines is still in the process of being developed, and for which the roles and values of thresholds have yet to be finalised. There are several options for integrating thre...
Tumor de células pequenas, redondas e azuis do pulmão: o desafio
Santos, Joana dos; Teixeira, C.; Amaro, T.O carcinoma de células pequenas do pulmão é um tumor neuroendócrino de alto grau que corresponde a cerca de 10-15% dos casos de cancro do pulmão. É de crescimento rápido e agressivo, surge predominantemente no hilo de doentes fumadores e tem mau prognóstico. Apesar das características citológicas desta entidade estarem bem descritas, pode ser um desafio distingui-la de outras neoplasias no exame citológico e es...
Untreated sewage contamination of beach sand from a leaking underground sewage ...
Brandão, J.; Albergaria, I.; Albuquerque, J.; José, S.; Grossinho, J.; Ferreira, F.C.; Raposo, A.; Rodrigues, R.; Silva, C.; Jordao, L.; Sousa, M.Thirty people (mostly children) experienced an episode of skin rash days after a sand sifting beach operation at Porto Pim Beach in Faial, Azores during June 2019. An environmental and epidemiologic investigation was conducted to identify the cause of the outbreak of skin rash. The epidemiologic investigation found that some of the patients experiencing symptoms had never entered the beach water. During the pol...
Metaplasia transicional em citologia cérvico-vaginal: um estudo de caso
Ferreira, Filipa; Ferreira, M.; Fialho, C.; Amaro, T.A metaplasia transicional cérvico-vaginal é uma condição benigna que está associada com atrofia e ocorre em mulheres na peri e pós-menopausa. O caso em análise reporta uma citologia cérvico-vaginal convencional corada pelo método de Papanicolaou de uma mulher de 57 anos de idade, cujo diagnóstico foi Células Pavimentosas Atípicas não excluindo Lesão Intraepitelial de Alto Grau (ASC-H). Posteriormente, o exame h...
Evolving hallmarks in urothelial bladder cancer: unveiling potential biomarkers
Afonso, Julieta Alexandra Pereira; Freitas, R.; Lobo, F.; Morais, A.; Amaro, T.; Reis, R. M.; Baltazar, Fátima; Longatto Filho, Adhemar; Santos, L.Urothelial bladder carcinoma (UBC), the most frequent type (90%) of bladder cancer and the second most common malignancy of the urogenital region, is a relatively well understood type of cancer, with numerous studies concerning pathogenetic pathways, natural history and bladder tumor biology being reported. Despite this, it continues to remain a challenge in the oncology field, mostly due to its relapsing and p...
CD147 and MCT1 - potential partners in bladder cancer aggressiveness and cispla...
Afonso, Julieta Alexandra Pereira; Santos, Lúcio; Gonçalves, Vera M.; Morais, António; Amaro, T.; Longatto Filho, Adhemar; Baltazar, FátimaThe relapsing and progressive nature of bladder tumors, and the heterogeneity in the response to cisplatin-containing regimens, are the major concerns in the care of urothelial bladder carcinoma (UBC) patients. The metabolic adaptations that alter the tumor microenvironment and thus contribute to chemoresistance have been poorly explored in UBC setting. We found significant associations between the immunoexpres...
Phospho-mTOR in non-tumour and tumour bladder urothelium : pattern of expressio...
Afonso, Julieta Alexandra Pereira; Longatto Filho, Adhemar; Silva, Vitor Moreira; Amaro, T.; Santos, L. L.Urothelial bladder carcinoma (UBC) is heterogeneous in its pathology and clinical behaviour. Evaluation of prognostic and predictive biomarkers is necessary, in order to produce personalised treatment options. The present study used immunohistochemistry to evaluate UBC sections containing tumour and non-tumour areas from 76 patients, for the detection of p-mTOR, CD31 and D2-40 (blood and lymphatic vessels ident...
CD147 overexpression allows an accurate discrimination of bladder cancer patien...
Afonso, J.; Longatto Filho, Adhemar; Baltazar, Fátima; Sousa, N.; Costa, Francisco; Morais, A.; Amaro, T.; Lopes, C.; Santos, L. L.Background: Urothelial bladder carcinoma (UBC) is a chemo-sensitive tumour, but the response to treatment is heterogeneous. CD147 has been associated with chemotherapy resistance. We aimed to define tumours with an aggressive phenotype by the combined analysis of clinicopathological and biological parameters. Methods: 77 patients with T1G3 or muscle-invasive UBC treated by radical cystectomy were studied. Immun...