5 documents found, page 1 of 1
Immune cellular profile of bisphosphonate-related osteonecrosis of the jaw
Silva, Paulo Goberlândio de Barros; Oliveira, C. C. de; Brizeno, Luiz André Cavalcante; Wong, Deysi V. T.; Lima Júnior, Roberto César PereiraOBJECTIVES: Characterize the cell profile and immunostaining of proinflammatory markers in an experimental model of bisphosphonate-related osteonecrosis of the jaw (BRONJ). MATERIALS AND METHODS: Male Wistar rats (n = 6-7) were treated chronically with saline solution or zoledronic acid (ZA) at 0.04, 0.20, and 1.00 mg kg(-1) (1.4 × 10(-7) , 6.9 × 10(-6) , and 3.4 × 10(-5) mol kg(-1) ), and subsequently, the fir...
Immune cell profile of dental pulp tissue treated with zoledronic acid
Silva, Paulo Goberlânio de Barros; Verde, Maria Elisa Quezado Lima; Brizeno, Luiz André Cavalcante; Wong, Deysi V. T.Abstract Immune cell profile of dental pulp tissue treated with zoledronic acid. International Endodontic Journal. Aim To characterize the pulp immune cell profile in the teeth of rats treated with zoledronic acid (ZA). Methodology Male Wistar rats (n = 6 per group) received four intravenous infusions of ZA at doses of 0.04, 0.20 or 1.00 mg kg 1 ZA or saline (control). On the 70th experimental day, they were euth...
Anti-inflammatory effect of the monoterpene myrtenol is dependent on the direct...
Gomes, Bruno S.; S. Neto, Benedito P.; Lopes, Everton M.; Cunha, Francisco V. M.; Araújo, Alyne R.; Wanderley, Carlos W. S.; Wong, Deysi V. T.Myrtenol is a bicyclic monoterpene with anti-in fl ammatory properties. However, the mechanisms involved are partially unknown. Here, we investigated the effect of myrtenol during experimental chronic arthritis and the possible modulating activity of oxidative stress and neutrophil migration. Complete Freund's Adjuvant (CFA)-sensitized rats were treated with vehicle (1 mL/kg, po), myrtenol (12.5, 25 or 50 mg/kg...
The adaptor protein myd88 is a key signaling molecule in the pathogenesis of ir...
Wong, Deysi V. T.; Lima-Júnior, Roberto C. P.; Carvalho, Cibele B. M.; Borges, Vanessa F.; Wanderley, Carlos W. S.; Bem, Amanda X. C.Intestinal mucositis is a common side effect of irinotecan-based anticancer regimens. Mucositis causes cell damage, bacterial/endotoxin translocation and production of cytokines including IL–1 and IL–18. These molecules and toll-like receptors (TLRs) activate a common signaling pathway that involves the Myeloid Differentiation adaptor protein, MyD88, whose role in intestinal mucositis is unknown. Then, we evalu...
Topical HPMC/S-nitrosoglutathione solution decreases inflammation and bone reso...
Martins, Conceição S.; Leitão, Renata Ferreira de Carvalho; Melo, Iracema M.; Santos, Glaylton S. Santo; Baldim, Victor Baldim; Bonfim, Luana E.S-nitrosoglutathione (GSNO) is a nitric oxide (NO) donor, which exerts antioxidant, anti-inflammatory, and microbicidal actions. Intragingival application of GSNO was already shown to decrease alveolar bone loss, inflammation and oxidative stress in an experimental periodontal disease (EPD) model. In the present study, we evaluated the potential therapeutic effect of topical applications of hydroxypropylmethylc...