8 documents found, page 1 of 1
TLR4 deficiency upregulates TLR9 expression and enhances irinotecan-related int...
Wong, Deysi Viviana Tenazoa; Holanda, Renata Brito Falcão; Cajado, Aurilene Gomes; Bandeira, Alessandro Maia; Pereira, Jorge Fernando BessaMade available in DSpace on 2022-05-01T07:58:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-10-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico; Background and purpose: Severe diarrhoea, a common gastrointestinal manifestation of anticanc...
Eugenol as a promising molecule for the treatment of dermatitis: antioxidant an...
Lopes, Amanda de Araújo; Fonseca, Francisco Noé da; Rocha, Talita Magalhães; Freitas, Lyara Barbosa de; Araújo, Emmanuel Vinicius OliveiraContact dermatitis produces an inflammatory reaction primarily via stimulation of keratinocytes and cells of the immune system, which promote the release of cytokines, reactive oxygen species (ROS), and other chemical mediators. Eugenol (EUG, phenylpropanoid of essential oils) has attracted attention due to its anti-inflammatory properties, as well as antioxidant effect. On the other hand, it is volatile and in...
Dual effect of silymarin on experimental non-alcoholic steatohepatitis induced ...
Assis-Júnior, Eudmar Marcolino; Melo, Anielle Torres; Pereira, Venúcia Bruna Magalhães; Wong, Deysi Viviana Tenazoa; Sousa, Nathalia Ribeiro PinhoIrinotecan-based regimens are commonly used for treatment of colorectal cancer, which is limited by mucositis and non-alcoholic steatohepatitis (NASH). Silymarin (SIL) prevents fatty liver disease in the clinical setting and in models of liver damage induced chemically. This study investigated the possible effect of SIL on irinotecan (IRI)-induced NASH. Swiss female mice were injected with saline (SAL 5 ml/kg i...
Acute and neuropathic orofacial antinociceptive effect of eucalyptol
Melo Júnior, José de Maria de Albuquerque de; Damasceno, Marina de Barros Mamede Vidal; Santos, Sacha Aubrey Alves Rodrigues; Barbosa, Talita MatiasTerpenes have a wide range of pharmacological properties, including antinociceptive action. The anti-in- flammatory and antinociceptive effects of eucalyptol are well established. The purpose of this study was to evaluate the antinociceptive effect of eucalyptol on acute and neu- ropathic orofacial pain in rodent models. Acute orofacial and corneal nociception was induced with formalin, cap- saicin, glutamate a...
Interleukin-18 (IL-18) is equally expressed in inflammatory breast cancer and n...
Aguiar, Marco Antônio Nasser; Wanderley, Carlos Wagner S.; Nobre, Lívia Maria Soares; Alencar, Mateus Rolim Mendes AlencarAim: Inflammatory breast cancer (IBC) is the most aggressive form of locally advanced breast can- cer. The signs of inflammation such as hyperemia and hyperthermia might suggest the possible participation of inflammatory mediators. This study investigates stromal and tumor expression of nuclear factor-kappa B (NF-B) and interleukin-18 (IL-18) in samples obtained from IBC and noninflammatory locally advanced breast...
Chronic treatment with zoledronic acid increases inflammatory markers in period...
Silva, Paulo Goberlânio de Barros; Ferreira Junior, Antonio Ernando Carlos; Oliveira, Camila Carvalho de Oliveira; Brizeno, Luiz André CavalcanteBackground: Bisphosphonates (BF) rise proinflammatory markers and irreversibly bind to bone. Chronically, BF can lead to an inflammatory status and can increase the local oxidative stress in periodontium. Therefore, the objective of this study was to evaluate whether the chronic infusion of Zoledronic Acid (ZA) increases inflam- matory markers in periodontium of rats. Methods and results: Chronically, infusion ...
Mediação dos receptores TLR2, NOD1, e da proteína MYD88 na modulação da mucosit...
Wong, Deysi Viviana TenazoaThe Colorectal Cancer (CRC) is one of the most prevalent neoplastic diseases in the world and is one leading cause of death. Irinotecan is a drug used as first line treatment for CRC and its liver metastases and has markedly improved the overall survival of patients. However, irinotecan-related side-effects, which include intestinal mucositis (IM), have impacted negatively on therapeutic outcome, leading to del...
Avaliação da equivalência farmacêutica da Carbamazepina e Diazepam comercializa...
Wong, Deysi Viviana TenazoaTwo drugs are considered pharmaceutically equivalent when both contain the same drug (base, salt or ester of the same active ingredient), at the same dosage and pharmaceutical form determined in vitro. In Brazil, the allopathic drugs are classified into three cathegories when registered in the Brazilian health surveillance agency (Agência Nacional de Vigilância Sanitária): new, similar or generic drugs. This wo...