5 documents found, page 1 of 1
Obstructive sleep apnea in a mouse model is associated with tissue-specific tra...
Koritala, Bala S. C.; Lee, Yin Yeng; Gaspar, Laetitia S.; Bhadri, Shweta S.; Su, Wen; Wu, Gang; Francey, Lauren J.; Ruben, Marc D.; Gong, Ming C.Intermittent hypoxia (IH) is a major clinical feature of obstructive sleep apnea (OSA). The mechanisms that become dysregulated after periods of exposure to IH are unclear, particularly in the early stages of disease. The circadian clock governs a wide array of biological functions and is intimately associated with stabilization of hypoxia-inducible factors (HIFs) under hypoxic conditions. In patients, IH occur...
Genome-wide analyses identify KIF5A as a novel ALS gene
Nicolas, Aude; Kenna, Kevin P.; Renton, Alan E.; Ticozzi, Nicola; Faghri, Faraz; Chia, Ruth; Dominov, Janice A.; Kenna, Brendan J.; Nalls, Mike A.To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls. Independently, we performed a rare variant burden analysis comparing 1,138 index familial ALS cases and 19,494 controls. Through both approaches, we identified kinesin family member 5A (KIF5A) as a novel gene associated with ALS. Int...
The serum matrix metalloproteinase-9 level is an independent predictor of recur...
Wu, Gang; Wang, Shun; Cheng, Mian; Peng, Bin; Liang, Jingjun; Huang, He; Jiang, Xuejun; Zhang, Lizhi; Yang, Bo; Cha, Yongmei; Jiang, HongOBJECTIVES: This study investigated whether the serum matrix metalloproteinase-9 level is an independent predictor of recurrence after catheter ablation for persistent atrial fibrillation. METHODS: Fifty-eight consecutive patients with persistent atrial fibrillation were enrolled and underwent catheter ablation. The serum matrix metalloproteinase-9 level was detected before ablation and its relationship with re...
The effect of storage time on adipose-derived stem cell recovery from human lip...
Carvalho, P. P.; Wu, Xiying; Wu, Gang; Dias, Isabel R.; Gomes, Manuela E.; Reis, R. L.; Gimble, Jeffrey M.Multipotent adipose-derived stromal/stem cells (ASCs) can be isolated with high yield from human subcutaneous lipoaspirates. This study reports our experience isolating, expanding, differentiating and immunophenotypically characterizing ASCs over a period of 4 days after having surgically obtained the lipoaspirate samples. The ultimate goal is to understand how to optimize the consistent isolation of ASCs from ...
Genipin-cross-linked collagen/chitosan biomimetic scaffolds for articular carti...
Yan, Leping; Wang, Yingjun; Rei, Li; Wu, Gang; Caridade, S. G.; Fan, Jiabing; Wang, Lingyun; Ji, Peihong; Oliveira, Joaquim M.; Oliveira, J. T.In this study, genipin-cross-linked collagen/chitosan biodegradable porous scaffolds were prepared for articular cartilage regeneration. The influence of chitosan amount and genipin concentration on the scaffolds physicochemical properties was evaluated. The morphologies of the scaffolds were characterized by scanning electron microscope (SEM) and cross-linking degree was investigated by ninhydrin assay. Additi...