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Magnetic natural lipid nanoparticles for oral treatment of colorectal cancer th...

Li, Baoyi; Zu, Menghang; Jiang, Aodi; Cao, Yingui; Wu, Jainxue; Shahbazi, Mohammad Ali; Shi, Xiaoxiao; Reis, R. L.; Kundu, Subhas C; Xiao, Bo

The therapeutic efficacy of oral nanotherapeutics against colorectal cancer (CRC) is restricted by inadequate drug accumulation, immunosuppressive microenvironment, and intestinal microbiota imbalance. To overcome these challenges, we elaborately constructed 6-gingerol (Gin)-loaded magnetic mesoporous silicon nanoparticles and functionalized their surface with mulberry leaf-extracted lipids (MLLs) and Pluronic ...


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