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Ambient fine particulate matter and daily mortality: a comparative analysis of ...

Yu, W; Huang, W; Gasparrini, A; Sera, F; Schneider, A; Breitner, S; Kyselý, J; Schwartz, J; Madureira, J; Gaio, V; Guo, YL; Xu, R; Chen, G; Yang, Z

Background: Model-estimated air pollution exposure products have been widely used in epidemiological studies to assess the health risks of particulate matter with diameters of ≤2.5 µm (PM2.5). However, few studies have assessed the disparities in health effects between model-estimated and station-observed PM2.5 exposures. Methods: We collected daily all-cause, respiratory and cardiovascular mortality data in 34...


Temperature frequency and mortality: Assessing adaptation to local temperature

Wu, Y; Wen, B; Gasparrini, A; Armstrong, B; Sera, F; Lavigne, E; Li, S; Guo, Y; Overcenco, A; Urban, A; Schneider, A; Entezari, A; Vicedo-Cabrera, AM

Assessing the association between temperature frequency and mortality can provide insights into human adaptation to local ambient temperatures. We collected daily time-series data on mortality and temperature from 757 locations in 47 countries/regions during 1979–2020. We used a two-stage time series design to assess the association between temperature frequency and all-cause mortality. The results were pooled ...


Global and Regional Cardiovascular Mortality Attributable to Nonoptimal Tempera...

Hundessa, S; Huang, W; Zhao, Q; Wu, Y; Wen, B; Alahmad, B; Armstrong, B; Gasparrini, A; Sera, F; Tong, S; Madureira, J; Kyselý, J; Schwartz, J

Background: The association between nonoptimal temperatures and cardiovascular mortality risk is recognized. However, a comprehensive global assessment of this burden is lacking. Objectives: The goal of this study was to assess global cardiovascular mortality burden attributable to nonoptimal temperatures and investigate spatiotemporal trends. Methods: Using daily cardiovascular deaths and temperature data from...


Comparison for the effects of different components of temperature variability o...

Wen, B; Wu, Y; Guo, Y; Gasparrini, A; Tong, S; Overcenco, A; Urban, A; Schneider, A; Entezari, A; Vicedo-Cabrera, AM; Zanobetti, A; Analitis, A; Zeka, A

Background: Temperature variability (TV) is associated with increased mortality risk. However, it is still unknown whether intra-day or inter-day TV has different effects. Objectives: We aimed to assess the association of intra-day TV and inter-day TV with all-cause, cardiovascular, and respiratory mortality. Methods: We collected data on total, cardiovascular, and respiratory mortality and meteorology from 758...


Fluctuating temperature modifies heat-mortality association around the globe

Wu, Y; Wen, B; Li, S; Gasparrini, A; Tong, S; Overcenco, A; Urban, A; Schneider, A; Entezari, A; Vicedo-Cabrera, AM; Zanobetti, A; Analitis, A; Zeka, A

Studies have investigated the effects of heat and temperature variability (TV) on mortality. However, few assessed whether TV modifies the heat-mortality association. Data on daily temperature and mortality in the warm season were collected from 717 locations across 36 countries. TV was calculated as the standard deviation of the average of the same and previous days’ minimum and maximum temperatures. We used l...


Global, regional, and national burden of mortality associated with short-term t...

Wu, Y; Li, S; Zhao, Q; Wen, B; Gasparrini, A; Tong, S; Overcenco, A; Urban, A; Schneider, A; Entezari, A; Vicedo-Cabrera, AM; Zanobetti, A; Analitis, A

Background: Increased mortality risk is associated with short-term temperature variability. However, to our knowledge, there has been no comprehensive assessment of the temperature variability-related mortality burden worldwide. In this study, using data from the MCC Collaborative Research Network, we first explored the association between temperature variability and mortality across 43 countries or regions. Th...


A draft genome sequence of the elusive giant squid, Architeuthis dux

Fonseca, RR; Couto, A; Machado, AM; Brejova, B; Albertin, CB; Silva, F; Gardner, P; Baril, T; Hayward, A; Campos, A; Ribeiro, ÂM; Barrio-Hernandez, I

Background: The giant squid (Architeuthis dux; Steenstrup, 1857) is an enigmatic giant mollusc with a circumglobal distribution in the deep ocean, except in the high Arctic and Antarctic waters. The elusiveness of the species makes it difficult to study. Thus, having a genome assembled for this deep-sea-dwelling species will allow several pending evolutionary questions to be unlocked. Findings: We present a dra...


Familial C4B deficiency and immune complex glomerulonephritis

Soto, K; Wu, Y; Ortiz, A; Aparício, S; Yu, C

Homozygous complement C4B deficiency is described in a Southern European young female patient with Membranoproliferative Glomerulonephritis (MPGN) type III characterized by renal biopsies with strong complement C4 and IgG deposits. Low C4 levels were independent of clinical evolution or type of immunosuppression and were found in three other family members without renal disease or infections. HLA typing reveale...


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