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Effect of prodigiosin on the alleviation of the intestinal inflammation of wean...
Yang, Peizhou; Wu, Yun; Qian, Jing; Cai, Kezhou; Cao, Lili; Zheng, Zhi; Luo, Shuizhong; Jiang, Shaotong; Zhu, XingxingWeaning results in intestinal dysfunction, mucosal atrophy, transient anorexia, and intestinal barrier defects. In this study, the effect of prodigiosin (PG) on the intestinal inflammation of weaned rats was investigated by using 1 H-NMR spectroscopy and biochemistry indexes to regulate the intestinal metabolism. After administration for 14 days, the body mass of the PG group was increased by 1.29‑ and 1.26-fol...
Modulation of MicroRNA-194 and cell migration by HER2-targeting trastuzumab in ...
Le, Xiao-Fen; Almeida, Maria Inês; Mao, Weiqu; Spizzo, Riccardo; Rossi, Simona; Nicoloso, Milena S.; Zhang, Shu; Wu, Yun; Calin, George A.Trastuzumab, a humanized monoclonal antibody directed against the extracellular domain of the HER2 oncoprotein, can effectively target HER2-positive breast cancer through several mechanisms. Although the effects of trastuzumab on cancer cell proliferation, angiogenesis and apoptosis have been investigated in depth, the effect of trastuzumab on microRNA (miRNA) has not been extensively studied. We have performed...