4 documents found, page 1 of 1
Data-driven modeling of the cellular pharmacokinetics of degradable chitosan-ba...
Summers, HD; Gomes, CP; Varela-Moreira, A; Spencer, AP; Gomez-Lazaro, M; Pêgo, AP; Rees, PNanoparticle drug delivery vehicles introduce multiple pharmacokinetic processes, with the delivery, accumulation, and stability of the therapeutic molecule influenced by nanoscale pro-cesses. Therefore, considering the complexity of the multiple interactions, the use of data-driven models has critical importance in understanding the interplay between controlling processes. We demonstrate data simulation techni...
Breaking Barriers: Bioinspired Strategies for Targeted Neuronal Delivery to the...
Spencer, AP; Torrado, M; Custódio, B; Silva-Reis, SC; Santos, S; Leiro, V; Pêgo, APCentral nervous system (CNS) disorders encompass a vast spectrum of pathological conditions and represent a growing concern worldwide. Despite the high social and clinical interest in trying to solve these pathologies, there are many challenges to bridge in order to achieve an effective therapy. One of the main obstacles to advancements in this field that has hampered many of the therapeutic strategies proposed...
Fine tuning neuronal targeting of nanoparticles by adjusting the ligand graftin...
Gomes, CP; Leiro, V; Lopes, CD; Spencer, AP; Pêgo, APPoly(ethylene glycol) (PEG) has been extensively used to coat the surface of nanocarriers to improve their physicochemical properties and allow the grafting of targeting moieties. Still, to date there is no common agreement on the ideal PEG coverage-density or length to be used for optimum vector performance. In this study, we aimed to investigate the impact of both PEG density and length on the vectoring capac...
Biodegradable PEG-dendritic block copolymers: Synthesis and biofunctionality as...
Leiro, V; Garcia, JP; Moreno, PM; Spencer, AP; Fernandez-Villamarin, M; Riguera, R; Fernandez-Megia, E; Pêgo, APOne important drawback of most of the currently used dendrimers for biomedical applications is their high stability under physiological conditions that can result in cytotoxicity or complications induced by the accumulation of non-degradable synthetic materials in the organism. Particularly in the gene therapy field, vector stability can further hinder the intracellular release of the nucleic acid from the dend...