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Intracellular delivery of anti-SMC2 antibodies against cancer stem cells
Montero, S; Seras-Franzoso, J; Andrade, F; Martinez-Trucharte, F; Vilar-Hernández, M; Quesada, M; Xandri, H; Arango, D; Abasolo, I; Rafael, DStructural maintenance of chromosomes protein 2 (SMC2) is a central component of the condensin complex involved in DNA supercoiling, an essential process for embryonic stem cell survival. SMC2 over-expression has been related with tumorigenesis and cancer malignancy and its inhibition is regarded as a potential therapeutic strategy even though no drugs are currently available. Here, we propose to inhibit SMC2 b...
Date: 2020
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Origin: Repositório Aberto da Universidade do Porto