3 documents found, page 1 of 1
Cholesterol redistribution triggered by CYP46A1 gene therapy improves major hal...
Nunes, Maria João; Carvalho, Andreia Neves; Reis, Joana; Costa, Daniela; Moutinho, Miguel; Mateus, Joana; Mendes de Almeida, Rita; Brito, SaraFunding Information: This work was funded by FEDER and by National Funds through Fundação para a Ciência e a Tecnologia (FCT) under project PTDC/MED-NEU/29455/2017 , Bolsa de Investigação da Sociedade Portuguesa de Doenças Metabólicas (SPDM), and BrainVectis Technologies . Publisher Copyright: © 2023 The Authors; Cholesterol 24-hydroxylase (CYP46A1) is an exclusively neuronal cytochrome P450 enzyme responsible ...
Editorial
Diógenes, Maria José; Almeida C, Guimas; Xapelli, SaraFunding Information: Funding: The authors would like to thank the following organizations for their funding: MD has been supported by Fundação para a Ciência e Tecnologia (FCT) Portugal (PTDC/MED-NEU/31929/2017) and Santa Casa da Misericórdia de Lisboa (MB37-2017). The Almeida Lab has been supported by FCT (JPCOFUND/0004/2015); Alzheimer's Association Research Grant (AARG-19-618007); Maratona da Saúde; iNOVA4He...
The Neuroprotective Action of Amidated-Kyotorphin on Amyloid β Peptide-Induced ...
Belo, Rita F.; Martins, Margarida L.F.; Shvachiy, Liana; Costa-Coelho, Tiago; de Almeida-Borlido, Carolina; Fonseca-Gomes, João; Neves, VeraKyotorphin (KTP, l-tyrosyl-l-arginine) is an endogenous dipeptide initially described to have analgesic properties. Recently, KTP was suggested to be an endogenous neuroprotective agent, namely for Alzheimer’s disease (AD). In fact, KTP levels were shown to be decreased in the cerebrospinal fluid of patients with AD, and recent data showed that intracerebroventricular (i.c.v.) injection of KTP ameliorates memor...