5 documents found, page 1 of 1
Different ability of multidrug-resistant and-sensitive counterpart cells to rel...
Sousa, D; Lima, RT; Lopes-Rodrigues, V; Gonzalez, E; Royo, F; Xavier, CPR; Falcón-Pérez, JM; Vasconcelos, MHCancer multidrug resistance (MDR) is one of the main challenges for cancer treatment efficacy. MDR is a phenomenon by which tumor cells become resistant to several unrelated drugs. Some studies have previously described the important role of extracellular vesicles (EVs) in the dissemination of a MDR phenotype. EVs’ cargo may include different players of MDR, such as microRNAS and drug-efflux pumps, which may be...
Synthesis of novel methyl 3-(Hetero)arylthieno[3,2-b]pyridine-2-carboxylates an...
Silva, BR; Rebelo, R; Rodrigues, JM; Xavier, CPR; Vasconcelos, MH; Queiroz, MJRPA series of novel functionalized methyl 3-(hetero)arylthieno[3,2-b]pyridine-2-carboxylates 2a–2h were synthesized by C-C Pd-catalyzed Suzuki-Miyaura cross-coupling of methyl 3-bromothie-no[3,2-b]pyridine-2-carboxylate with (hetero)aryl pinacol boranes, trifluoro potassium boronate salts or boronic acids. Their antitumoral potential was evaluated in two triple negative breast cancer (TNBC) cell lines—MDA-MB-231 ...
Drug repurposing opportunities in pancreatic ductal adenocarcinoma
Rebelo, R; Polónia, B; Santos, LL; Vasconcelos, MH; Xavier, CPRPancreatic ductal adenocarcinoma (PDAC) is considered one of the deadliest tumors worldwide. The diagnosis is often possible only in the latter stages of the disease, with patients already presenting an advanced or metastatic tumor. It is also one of the cancers with poorest prognosis, presenting a five-year survival rate of around 5%. Treatment of PDAC is still a major challenge, with cytotoxic chemotherapy re...
The Role of Extracellular Vesicles in the Hallmarks of Cancer and Drug Resistance
Xavier, CPR; Caires, HR; Barbosa, MAG; Bergantim, R; Guimarães, JE; Vasconcelos, MHExtracellular vesicles (EVs) mediate intercellular signaling and communication, allowing the intercellular exchange of proteins, lipids, and genetic material. Their recognized role in the maintenance of the physiological balance and homeostasis seems to be severely disturbed throughout the carcinogenesis process. Indeed, the modus operandi of cancer implies the highjack of the EV signaling network to support tu...
Synthesis of new proteomimetic quinazolinone alkaloids and evaluation of their ...
Long, S; Resende, D; Kijjoa, A; Silva, A; Fernandes, R; Xavier, CPR; Vasconcelos, MH; Sousa, E; Pinto, MNew quinazolinone derivatives of the marine-derived alkaloids fiscalin B (3) and fumiquinazoline G (1), with neuroprotective and antitumor effects, were synthesized. Eleven quinazolinone-containing indole alkaloids were synthesized, proceeding the anti analogs via a one-pot method, and the syn analogs by the Mazurkiewicz-Ganesan approach. The neuroprotection capacity of these compounds on the rotenone-damage hu...