6 documents found, page 1 of 1
Suicide time-series structural change analysis in Portugal (1913-2018): Impact ...
Gusmão, R; Ramalheira, C; Conceição, V; Severo, M; Mesquita, E; Xavier, M; Barros, HBackground Suicide is a potentially preventable cause of death. Epidemiology might help to identify death determinants and to monitor prevention strategies. Few studies address secular trends in suicide deaths, and even fewer describe trend-changes in relation to data collection/registration bias. Moreover, suicide is admittedly underreported. It is crucial to validate results in the context of other external c...
PAMAM dendrimers: blood-brain barrier transport and neuronal uptake after focal...
Santos, SD; Xavier, M; Leite, D; Moreira, D; Custódio, B; Torrado, M; Castro, R; Leiro, V; Rodrigues, J; Tomás, H; Pêgo, APDrug delivery to the central nervous system is restricted by the blood-brain barrier (BBB). However, with the onset of stroke, the BBB becomes leaky, providing a window of opportunity to passively target the brain. Here, cationic poly(amido amine) (PAMAM) dendrimers of different generations were functionalized with poly(ethylene glycol) (PEG) to reduce cytotoxicity and prolong blood circulation half-life, aimin...
Acute psychotic disorder associated with vigabatrin.
Xavier, M; Bento, M S; Pereira, D P; De Almeida, J MVigabatrin, a drug mainly used in the treatment of therapy-resistant epilepsy, has been associated to a large range of adverse effects, including acute psychotic disorders. The authors report the case of a 44-year-old patient with drug-resistant temporal lobe epilepsy that developed an acute psychotic episode about three weeks after initiating medication with vigabatrin. After the withdrawal of vigabatrin and t...
Current prospects in the community treatment of schizophrenia.
de Almeida, J M; Xavier, MThe advances of pharmacological and psychosocial therapies in recent years have deeply changed the perspectives on the treatment of schizophrenia in the community. The hospital-centred models are progressively being replaced with comprehensive community care models. After discussing the main aspects of this evolution at a conceptual level, the authors describe the currently available therapeutic interventions o...
Evaluation and quality assurance of mental health services.
De Almeida, J M; Xavier, MEvaluation and quality assurance are primary issues in mental health care today. An up-date of current knowledge and experience in this domain is the main objective of this paper. The authors begin by describing the reasons that justify the current interest in this subject, defining concepts and summarizing the most relevant historical antecedents. This is followed by a discussion of the main methodological asp...
Psychiatric morbidity in general hospital inpatients.
de Almeida, J M; Xavier, M; Nabais, F; Santos, F; Morais, JPsychiatric morbidity was studied in 73 patients of three Units (Medicine, Surgery and Obstetrics) of a general hospital (S. Francisco Xavier Hospital, Lisbon). In the first stage, the patients were clinically evaluated by their doctors. In the second stage, psychiatrists using the General Health Questionnaire (G.H.Q. 30) interviewed all the patients according to the clinical evaluation, 41% of the patients had...