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Anti-serum validation for use in immunohistochemistry for Trypanosoma cruzi det...
Azevedo, Paulo Hernane Rabelo; Xavier, Marcelo Antônio Pascoal; Silva, Glenda Nicioli da; Costa, Priscilla Almeida da; Carneiro, Cláudia MartinsIntroduction: The detection of Trypanosoma cruzi in tissue samples is important in many situations, such as testing of the reactivation of the infection. The detection of T. cruzi nests in endomyocardial biopsies (EMB) may be useful to evaluate graft rejection. Given their scarcity, such nests are not routinely identified. To increase the diagnosis sensitivity, immunohistochemistry (IHC) may serve as a promisin...
Accomplishing the genotype-specific serodiagnosis of single and dual Trypanosom...
Alessio, Glaucia Diniz; Araújo, Fernanda Fortes de; Sales Júnior, Policarpo Ademar; Gomes, Matheus de Souza; Amaral, Laurence Rodrigues doThe methods currently available for genotype-specific diagnosis of T. cruzi infection still present relevant limitations, especially to identify mixed infection. In the present investigation, we have evaluated the performance of Chagas-Flow ATE-IgG2a test for early and late differential diagnosis of single and dual genotype-specific T. cruzi infections. Serum samples from Swiss mice at early and late stages of ...
Performance of TcI/TcVI/TcII Chagas-Flow ATE-IgG2a for universal and genotype-s...
Alessio, Glaucia Diniz; Araújo, Fernanda Fortes de; Côrtes, Denise Fonseca; Sales Júnior, Policarpo Ademar; Lima, Daniela CristinaDistinct Trypanosoma cruzi genotypes have been considered relevant for patient management and therapeutic response of Chagas disease. However, typing strategies for genotype- specific serodiagnosis of Chagas disease are still unavailable and requires standardization for practical application. In this study, an innovative TcI/TcVI/TcII Chagas Flow ATE-IgG2a technique was developed with applicability for universa...
Virulence in murine model shows the existence of two distinct populations of Br...
Ferreira, Jaqueline Maria Siqueira; Drumond, Betânia Paiva; Guedes, Maria Isabel Maldonado Coelho; Xavier, Marcelo Antônio PascoalBrazilian Vaccinia virus had been isolated from sentinel mice, rodents and recently from humans, cows and calves during outbreaks on dairy farms in several rural areas in Brazil, leading to high economic and social impact. Some phylogenetic studies have demonstrated the existence of two different populations of Brazilian Vaccinia virus strains circulating in nature, but little is known about their biological ch...