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Clinical difference between identical twins with sickle cell anemia
Laurentino,Marilia R.; Almeida Filho,Tarcisio Paulo; Maia Filho,Pedro A.; Nascimento,Francisco O. F.; Advincula,Adlene F.; Machado,Clarissa Maria G.ABSTRACT Sickle cell anemia (SCA) is a genetic disease that causes important clinical manifestations due to chronic hemolysis and vascular occlusion. The aim of this study was to report a rare case of monozygotic twins diagnosed with SCA, presenting a different clinical characteristic. An interview with the patients was carried out and the medical records were consulted. One patient has a history of malleolar u...
Analysis of BCL11A gene polymorphisms and hemolysis parameters in patients with...
Laurentino,Marilia R.; Barbosa,Maritza C.; Santos,Talyta Ellen J.; Perdigão,Anne Caroline B.; Araújo,Fernanda M. C.; Lemes,Romelia P. G.ABSTRACT Introduction: Patients with sickle-cell disease (SCD) present chronic hemolysis with increased serum biomarkers. Genetic polymorphisms of the BLC11A gene modulate fetal hemoglobin (HbF), thus reducing hemolysis Objective: To associate the polymorphisms of BCL11A gene with the hemolysis markers: reticulocyte, bilirubin, uric acid, lactate dehydrogenase (LDH), and methemoglobin (MetHb) in SCD patients. M...