2 documents found, page 1 of 1
Conformational changes in the essential E. coli septal cell wall synthesis comp...
Britton, Brooke M.; Yovanno, Remy A.; Costa, Sara F.; McCausland, Joshua; Lau, Albert Y.; Xiao, Jie; Hensel, ZachFunding Information: The authors thank all members of the Hensel, Xiao, and Lau laboratories for helpful discussions and feedback on the manuscript. Z.H. received support for this work from FCT—Fundação para a Ciência e a Tecnologia, I.P., through MOSTMICRO-ITQB R&D Unit (UIDB/04612/2020, UIDP/04612/2020, Z.H.) and LS4FUTURE Associated Laboratory (LA/P/0087/2020, Z.H.), from a joint research agreement with the ...
Cell fate potentials and switching kinetics uncovered in a classic bistable gen...
Fang, Xiaona; Liu, Qiong; Bohrer, Christopher; Hensel, Zach; Han, Wei; Wang, Jin; Xiao, JieBistable switches are common gene regulatory motifs directing two mutually exclusive cell fates. Theoretical studies suggest that bistable switches are sufficient to encode more than two cell fates without rewiring the circuitry due to the non-equilibrium, heterogeneous cellular environment. However, such a scenario has not been experimentally observed. Here by developing a new, dual single-molecule gene-expres...