3 documents found, page 1 of 1
Squaramide-based synthetic chloride transporters activate TFEB but block autoph...
Zhang, Shaoyi; Wang, Yan; Xie, Wei; Howe, Ethan N W; Busschaert, Nathalie; Sauvat, Allan; Leduc, Marion; Silva, Lígia C. Gomes da; Chen, GuoCystic fibrosis is a disease caused by defective function of a chloride channel coupled to a blockade of autophagic flux. It has been proposed to use synthetic chloride transporters as pharmacological agents to compensate insufficient chloride fluxes. Here, we report that such chloride anionophores block autophagic flux in spite of the fact that they activate the pro-autophagic transcription factor EB (TFEB) co...
Author Correction: Squaramide-based synthetic chloride transporters activate TF...
Zhang, Shaoyi; Wang, Yan; Xie, Wei; Howe, Ethan N W; Busschaert, Nathalie; Sauvat, Allan; Leduc, Marion; Silva, Lígia C. Gomes da; Chen, GuoIn the version of this article originally submitted, it was stated that the first three authors (Shaoyi_ Than, Yan Wang, Wei Xie) had contributed equally. However, in the published version this information was missing.
Oncolysis with DTT-205 and DTT-304 generates immunological memory in cured animals
Zhou, Heng; Mondragón, Laura; Xie, Wei; Mauseth, Brynjar; Leduc, Marion; Sauvat, Allan; Silva, Lígia C. Gomes da; Forveille, SabrinaOncolytic peptides and peptidomimetics are being optimized for the treatment of cancer by selecting agents with high cytotoxic potential to kill a maximum of tumor cells as well as the capacity to trigger anticancer immune responses and hence to achieve long-term effects beyond therapeutic discontinuation. Here, we report on the characterization of two novel oncolytic peptides, DTT-205 and DTT-304 that both sel...