2 documents found, page 1 of 1
Relationship between maternal adverse childhood experiences and infant developm...
Ximenes, Renata de Barros Bruno; Ximenes, José Christian Machado; Nascimento, Simony Lira; Roddy, Sarah M.; Leite, Álvaro Jorge MadeiroAbstract Introduction: Twenty years ago, the first study was conducted to access adverse childhood experiences (ACEs) and their relation to outcomes in adulthood. The effects of exposure to childhood trauma can also be transmitted to other generations. There are some studies that suggest the hypothesis that intergenerational transmission may begin during intrauterine life through the change in placental-fetal p...
Valproic acid neuroprotection in the 6-OHDA model of Parkinson’s disease is pos...
Ximenes, José Christian Machado; Neves, Kelly Rose Tavares; Leal, Luzia Kalyne Almeida Moreira; Carmo, Marta Regina Santos doParkinson’s disease is a neurodegenerative disorder where the main hallmark is the dopaminergic neuronal loss. Besides motor symptoms, PDalso causes cognitive decline. Although current therapies focus on the restoration of dopamine levels in the striatum, prevention or disease-modifying therapies are urgently needed. Valproic acid (VA) is a wide spectrum antiepileptic drug, exerting many biochemical and physiol...