9 documents found, page 1 of 1
In vitro studies on Bothrops venoms cytotoxic effect on tumor cells
Jorge, Roberta J. B.; Martins, Alice M. C.; Morais, Isabel C. O.; Ximenes, Rafael M.; Rodrigues, Felipe A. R.; Soares, Bruno M.Made available in DSpace on 2022-04-29T02:17:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-12-29; Background: Animal venoms are complex mixtures of proteins and non proteins components with several biological activities. Snake venoms represent an essentially unexplored source of bioactive compounds that may cure disease conditions which do not respond to currently available therapies. These venoms p...
Venomics and antivenomics of Bothrops erythromelas from five geographic populat...
Jorge, Roberta Jeane B.; Monteiro, Helena S. A.; Machado, Larissa Gonçalves; Guarnieri, Míriam C.; Ximenes, Rafael M.; Nojosa, Diva M. BorgesThe Caatinga lancehead, Bothrops erythromelas, is a medically relevant species, responsible for most of the snakebite accidents in most parts of its distribution range in northeastern Brazil. The spectrum and geographic variability of its venom toxins were investigated applying a venomics approach to venom pools from five geographic areas within the Caatinga ecoregion. Despite its wide habitat, populations of B...
Anti-ophidian activity of Bredemeyera floribunda Willd. (Polygalaceae) root ext...
Alves, Natacha Teresa Queiroz; Ximenes, Rafael M.; Jorge, Roberta J. B.; Silveira, J. A. M.; Santos, J. V. A.; Rodrigues, F. A. P.; Costa, P. H. S.Bredemeyera floribunda roots are popularly used to treat snakebites in the semiarid region of Northeast Brazil, and previous studies indicate the anti-ophidian actions of triterpenoid saponins found in its roots. To assess B. floribunda root extract (BFRE) activity against the effects of Bothrops jararacussu venom (BjuV), antiphospholipasic, antiproteolytic, antihemorrhagic, antinecrotic, and anti-edematogenic ...
Solanidane and iminosolanidane alkaloids from solanum campaniforme
Torres, Maria Conceição M.; Jorge, Roberta Jeane B.; Ximenes, Rafael M.; Alves, Natacha Teresa Queiroz; Santos, João Victor de A.; Marinho, Aline D.From the leaves of Solanum campaniforme (Solanaceae), eight solanidane alkaloids were isolated, four of which contain a p-hydroxyphenylethylamine unit. Their structures were established as: 22b,23b-epoxysolanida- 1,4-dien-3-one; 22a,23a-epoxy-10-epi-solanida-1,4,9-trien-3-one; 22a,23a-epoxy-solanida-4- en-3-one; 22b,23b-epoxy-solanida-4-en-3-one; (E)-N-[80(4-hydroxyphenyl)ethyl]-22a,23a-epoxy-solanida-1, 4,9-tr...
Inhibition of Neurotoxic Secretory Phospholipases A(2) Enzymatic, Edematogenic,...
Ximenes, Rafael M.; Rabello, Marcelo M.; Araujo, Renata M.; Silveira, Edilberto R.; Fagundes, Fabio H. R. [UNESP]; Diz-Filho, Eduardo B. S. [UNESP]Made available in DSpace on 2013-08-28T14:13:53Z (GMT). No. of bitstreams: 1 WOS000308300500001.pdf: 5416562 bytes, checksum: 067c932d70822bc39bb0b2a57e0ab891 (MD5); Made available in DSpace on 2013-09-30T17:41:27Z (GMT). No. of bitstreams: 2 WOS000308300500001.pdf: 5416562 bytes, checksum: 067c932d70822bc39bb0b2a57e0ab891 (MD5) WOS000308300500001.pdf.txt: 36390 bytes, checksum: 647f2b3b8e3fb1f7f5eb07947fc6a27f...
Harpalycin 2 inhibits the enzymatic and platelet aggregation activities of PrTX...
Ximenes, Rafael M.; Alves, Renata S.; Pereira, Ticiana P.; Araujo, Renata M.; Silveira, Edilberto R.; Rabello, Marcelo M.; Hernandes, Marcelo Z.Made available in DSpace on 2013-08-28T14:14:23Z (GMT). No. of bitstreams: 1 WOS000312325000001.pdf: 1687045 bytes, checksum: 81c838bb86f5cc0e9eecf68046ea6082 (MD5); Made available in DSpace on 2013-09-30T17:41:27Z (GMT). No. of bitstreams: 2 WOS000312325000001.pdf: 1687045 bytes, checksum: 81c838bb86f5cc0e9eecf68046ea6082 (MD5) WOS000312325000001.pdf.txt: 42001 bytes, checksum: b4a008ad203891063588dc25c979630f...
Isolation, homology modeling and renal effects of a C-type natriuretic peptide ...
Alves, Renata S.; Ximenes, Rafael M.; Jorge, Antonio R.C.; Nascimento, Nilberto R.F.; Martins, René D.; Rabello, Marcelo M.; Hernandes, Marcelo Z.Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:30:52Z No. of bitstreams: 0; Made available in DSpace on 2014-05-27T11:30:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-11-01; Mammalian natriuretic peptides (NPs) have been extensively investigated for use as therapeutic agents in the treatment of cardiovascular diseases. Here, we describe the isolation, sequ...
Vasoconstrictor effect of Africanized honeybee (Apis mellifera L.) venom on rat...
Sousa, Paulo Cesar P.; Brito, Teresinha S.; Freire, Daniel S.; Ximenes, Rafael M.; Magalhaes, Pedro Jorge C.; Monteiro, Helena S. A.; Alves, Renata S.Made available in DSpace on 2014-12-03T13:11:24Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-09-25Bitstream added on 2014-12-03T13:23:33Z : No. of bitstreams: 1 WOS000325247700002.pdf: 661869 bytes, checksum: 1ee9f647378be469eba77b99b039d342 (MD5); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Cearense Foundat...
Vasoconstrictor effect of Africanized honeybee (Apis mellifera L.) venom on rat...
Sousa, Paulo César P.; Brito, Teresinha S.; Freire, Daniel S.; Ximenes, Rafael M.; Magalhães, Pedro Jorge C.; Monteiro, Helena S. A.Background: Apis mellifera stings are a problem for public health worldwide, particularly in Latin America due to the aggressiveness of its Africanized honeybees. Massive poisoning by A. mellifera venom (AmV) affects mainly the cardiovascular system, and several works have described its actions on heart muscle. Nevertheless, no work on the pharmacological action mechanisms of the AmV in isolated aorta has been ...