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Global chronic total occlusion crossing algorithm: JACC state-of-the-Art review

Wu, Eugene B.; Brilakis, Emmanouil S.; Mashayekhi, Kambis; Tsuchikane, Etsuo; Alaswad, Khaldoon; Araya, Mario; Avran, Alexandre; Azzalini, Lorenzo

The authors developed a global chronic total occlusion crossing algorithm following 10 steps: 1) dual angiography; 2) careful angiographic review focusing on proximal cap morphology, occlusion segment, distal vessel quality, and collateral circulation; 3) approaching proximal cap ambiguity using intravascular ultrasound, retrograde, and move-the-cap techniques; 4) approaching poor distal vessel quality using th...


Global chronic total occlusion crossing algorithm

Wu, Eugene B.; Brilakis, Emmanouil S.; Mashayekhi, Kambis; Tsuchikane, Etsuo; Alaswad, Khaldoon; Araya, Mario; Avran, Alexandre; Azzalini, Lorenzo

The authors developed a global chronic total occlusion crossing algorithm following 10 steps: 1) dual angiography; 2) careful angiographic review focusing on proximal cap morphology, occlusion segment, distal vessel quality, and collateral circulation; 3) approaching proximal cap ambiguity using intravascular ultrasound, retrograde, and move-the-cap techniques; 4) approaching poor distal vessel quality using th...


Guiding principles for chronic total occlusion percutaneous coronary interventi...

Brilakis, Emmanouil S.; Mashayekhi, Kambis; Tsuchikane, Etsuo; Abi Rafeh, Nidal; Alaswad, Khaldoon; Araya, Mario; Avran, Alexandre; Azzalini, Lorenzo

Outcomes of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) have improved because of advancements in equipment and techniques. With global collaboration and knowledge sharing, we have identified 7 common principles that are widely accepted as best practices for CTO-PCI.  1. Ischemic symptom improvement is the primary indication for CTO-PCI.  2. Dual coronary angiography and in-depth and s...


GABA signalling modulates plant growth by directly regulating the activity of p...

Ramesh, Sunita A.; Tyerman, Stephen D.; Xu, Bo; Bose, Jayakumar; Kaur, Satwinder; Conn, Vanessa; Domingos, Patricia; Ullah, Sana; Wege, Stefanie

The non-protein amino acid, gamma-aminobutyric acid (GABA) rapidly accumulates in plant tissues in response to biotic and abiotic stress, and regulates plant growth. Until now it was not known whether GABA exerts its effects in plants through the regulation of carbon metabolism or via an unidentified signalling pathway. Here, we demonstrate that anion flux through plant aluminium-activated malate transporter (A...


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