4 documents found, page 1 of 1
Transient mild photothermia improves therapeutic performance of oral nanomedici...
Ma, Ya; Gou, Shuangquan; Zhu, Zhenhua; Sun, Jianfeng; Shahbazi, Mohammad-Ali; Si,Tieyan; Xu, Cheng; Ru, Jinlong; Shi, Xiaoxiao; Reis, R. L.The treatment outcomes of oral medications against ulcerative colitis (UC) have long been restricted by low drug accumulation in the colitis mucosa and subsequent unsatisfactory therapeutic efficacy. Here, high-performance pluronic F127 (P127)-modified gold shell (AuS)-polymeric core nanotherapeutics loading with curcumin (CUR) is constructed. Under near-infrared irradiation, the resultant P127-AuS@CURs generat...
CaO2-Cu2O micromotors accelerate infected wound healing through antibacterial f...
Liu, Ga; Zu, Menghang; Wang, Lingshuang; Xu, Cheng; Zhang, Jiamei; Reis, R. L.; Kundu, Subhas C; Xiao, Bo; Duan, Lian; Yang, XiaoDuring the wound tissue healing process, the relatively weak driving forces of tissue barriers and concentration gradients lead to a slow and inefficient penetration of bioactive substances into the wound area, consequently showing an impact on the effectiveness of deep wound healing. To overcome these challenges, we constructed biocompatible CaO2–Cu2O “micromotors”. These micromotors reacted with the fluids at...
Transparent silk fibroin film-facilitated infected-wound healing through antiba...
Zhang, Jiamei; Wang, Lingshuang; Xu, Cheng; Cao, Yingu; Liu, Shengsheng; Reis, R. L.; Kundu, Subhas C; Yang, Xiao; Xiao, Bo; Duan, LianThe clinical application of regenerated silk fibroin (RSF) films for wound treatment is restricted by its undesirable mechanical properties and lack of antibacterial activity. Herein, different pluronic polymers were introduced to optimize their mechanical properties and the RSF film with 2.5% pluronic F127 (RSFPF127) stood out to address the above issues owing to its satisfactory mechanical properties, hydroph...
Mulberry biomass-derived nanomedicines mitigate colitis through improved inflam...
Yang, Wenjing; Ma, Ya; Xu, Haiting; Zhu, Zhenhua; Wu, Jiaxue; Xu, Cheng; Sun, Wei; Zhao, Erhu; Wang, Min; Reis, R. L.; Kundu, Subhas C; Shi, XiaoxiaoThe therapeutic outcomes of conventional oral medications against ulcerative colitis (UC) are restricted by inefficient drug delivery to the colitis mucosa and weak capacity to modulate the inflammatory microenvironment. Herein, a fluorinated pluronic (FP127) was synthesized and employed to functionalize the surface of mulberry leaf-derived nanoparticles (MLNs) loading with resveratrol nanocrystals (RNs). The o...