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Cu+/Ca2+ Dual‐overload strategy assisted by metabolic‐symbiotic‐destruction for...
Yan, Jiahui; Chen, Haoyu; Guimarães, Carlos Ferreira; Reis, R. L.; Zhu, Zhihua; Wang, Tianyi; Zhang, Fenglan; Zhou, Qihui; Kong, Xiaoying; Shi, JinshengIon interference including copper (Cu+)/calcium (Ca2+) overload activate cell-specific death channels, damage mitochondria and disrupt cellular homeostasis, showing great potential in anti-tumor therapy. However, the complex metabolic environment and the powerful self-protection of tumors cause clinical failure of ion interference. Thus, metabolic disruption is expected an innovative strategy for the enhancemen...
Date: 2024
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Origin: RepositóriUM - Universidade do Minho