3 documents found, page 1 of 1
PITX2C loss-of-function mutations responsible for idiopathic atrial fibrillation
Qiu, Xing-Biao; Xu, Ying-Jia; Li, Ruo-Gu; Xu, Lei; Liu, Xu; Fang, Wei-Yi; Yang, Yi-Qing; Qu, Xin-KaiOBJECTIVE: This study aimed to identify novel PITX2c mutations responsible for idiopathic atrial fibrillation. METHODS: A cohort of 210 unrelated patients with idiopathic atrial fibrillation and 200 unrelated, ethnically matched healthy individuals used as controls were recruited. The whole coding exons and splice junctions of the PITX2c gene, which encodes a paired-like homeobox transcription factor required f...
Prevalence and spectrum of Nkx2.5 mutations associated with idiopathic atrial f...
Xie, Wen-Hui; Chang, Cheng; Xu, Ying-Jia; Li, Ruo-Gu; Qu, Xin-Kai; Fang, Wei-Yi; Liu, Xu; Yang, Yi-QingOBJECTIVE: The aim of this study was to evaluate the prevalence and spectrum of Nkx2.5 mutations associated with idiopathic atrial fibrillation (AF). METHODS: A cohort of 136 unrelated patients with idiopathic atrial fibrillation and 200 unrelated, ethnically matched healthy controls were enrolled. The coding exons and splice junctions of the Nkx2.5 gene were sequenced in 136 atrial fibrillation patients, and t...
Novel GATA5 loss-of-function mutations underlie familial atrial fibrillation
Gu, Jian-Yun; Xu, Jia-Hong; Yu, Hong; Yang, Yi-QingOBJECTIVE: This study aimed to identify novel GATA5 mutations that underlie familial atrial fibrillation. METHODS: A total of 110 unrelated patients with familial atrial fibrillation and 200 unrelated, ethnically matched healthy controls were recruited. The entire coding region of the GATA5 gene was sequenced in 110 atrial fibrillation probands. The available relatives of the mutation carriers and 200 controls ...