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Chronic stress and glucocorticoid actions in brain plasticity and Tau pathology

Dioli, Chrysoula

Trabalho de Doutoramento realizado em cotutela: Doutoramento em Envelhecimento e Doenças Crónicas e École Doctorale Cerveau, Cognition, Comportement (Paris, no 158); Chronic stress and high levels of the stress hormone, glucocorticoid (GC), are implicated in susceptibility to brain pathologies such as depression or Alzheimer’s disease (AD), as they promote neural plasticity damage and glial reactivity, which ca...


Chronic stress triggers divergent dendritic alterations in immature neurons of ...

Dioli, Chrysoula; Patrício, Patrícia; Sousa, Nuno; Kokras, Nikolaos; Dalla, Christina; Guerreiro, Sara; Santos-Silva, Miguel A.; Rego, Ana Cristina

Chronic stress, a suggested precipitant of brain pathologies, such as depression and Alzheimer's disease, is known to impact on brain plasticity by causing neuronal remodeling as well as neurogenesis suppression in the adult hippocampus. Although many studies show that stressful conditions reduce the number of newborn neurons in the adult dentate gyrus (DG), little is known about whether and how stress impacts ...


Activated PPARγ Abrogates Misprocessing of Amyloid Precursor Protein, Tau Misso...

Moosecker, Susanne; Gomes, Patrícia; Dioli, Chrysoula; Yu, Shuang; Sotiropoulos, I.; Almeida, Osborne F. X.

Type 2 diabetes increases the risk for dementia, including Alzheimer's disease (AD). Pioglitazone (Pio), a pharmacological agonist of the peroxisome proliferator-activated receptor γ (PPARγ), improves insulin sensitivity and has been suggested to have potential in the management of AD symptoms, albeit through mostly unknown mechanisms. We here investigated the potential of Pio to counter synaptic malfunction an...


Dysregulation of autophagy and stress granule-related proteins in stress-driven...

Silva, Joana Margarida Gonçalves Mota; Rodrigues, Sara; Marques, Maria Belém Sousa Sampaio; Gomes, Patrícia; Carvalho, Andreia Alexandra Neves

Imbalance of neuronal proteostasis associated with misfolding and aggregation of Tau protein is a common neurodegenerative feature in Alzheimer's disease (AD) and other Tauopathies. Consistent with suggestions that lifetime stress may be an important AD precipitating factor, we previously reported that environmental stress and high glucocorticoid (GC) levels induce accumulation of aggregated Tau; however, the m...


Chronic stress triggers divergent dendritic alterations in immature neurons of ...

Dioli, Chrysoula; Patrício, Patrícia; Sousa, Nuno; Kokras, Nikolaos; Dalla, Christina; Guerreiro, Sara; Santos-Silva, Miguel A.; Rego, Ana Cristina

Chronic stress, a suggested precipitant of brain pathologies, such as depression and Alzheimer's disease, is known to impact on brain plasticity by causing neuronal remodeling as well as neurogenesis suppression in the adult hippocampus. Although many studies show that stressful conditions reduce the number of newborn neurons in the adult dentate gyrus (DG), little is known about whether and how stress impacts ...


Endolysosomal degradation of Tau and its role in glucocorticoid-driven hippocam...

Vaz-Silva, João; Gomes, Patrícia; Jin, Qi; Zhu, Mei; Zhuravleva, Viktoriya; Quintremil, Sebastian; Meira, Torcato Duarte Novo; Silva, Joana

Emerging studies implicate Tau as an essential mediator of neuronal atrophy and cognitive impairment in Alzheimer's disease (AD), yet the factors that precipitate Tau dysfunction in AD are poorly understood. Chronic environmental stress and elevated glucocorticoids (GC), the major stress hormones, are associated with increased risk of AD and have been shown to trigger intracellular Tau accumulation and downstre...


Tau-dependent suppression of adult neurogenesis in the stressed hippocampus

Dioli, Chrysoula; Patrício, P.; Trindade, R.; Pinto, L. G.; Silva, J. M.; Morais, M.; Ferreiro, E.; Borges, S.; Mateus-Pinheiro, A.; Rodrigues, A. J.

uncorrected proof; Stress, a well-known sculptor of brain plasticity, is shown to suppress hippocampal neurogenesis in the adult brain; yet, the underlying cellular mechanisms are poorly investigated. Previous studies have shown that chronic stress triggers hyperphosphorylation and accumulation of the cytoskeletal protein Tau, a process that may impair the cytoskeleton-regulating role (s) of this protein with i...


Tau deletion prevents stress-induced dendritic atrophy in prefrontal cortex: ro...

Lopes, Sofia Oliveira; Teplytska, Larysa; Silva, João Luís Vaz Lima da; Dioli, Chrysoula; Trindade, Rita; Morais, Mónica; Webhofer, Christian

Tau protein in dendrites and synapses has been recently implicated in synaptic degeneration and neuronal malfunction. Chronic stress, awell-known inducer of neuronal/synaptic atrophy, triggers hyperphosphorylation of Tau protein and cognitive deficits. However, the cause–effect relationship between these events remains to be established. To test the involvement of Tau in stress-induced impairments of cognition,...


The role of Tau protein in the stress-induced changes in adult hippocampal neur...

Dioli, Chrysoula

Dissertação de mestrado em Ciências da Saúde; Exposure to chronic stressful conditions is suggested to increase susceptibility to brain pathology as it is associated with neuroplastic deficits as well as impaired cognition and mood. Specifically, structural/functional changes of hippocampal formation are shown to contribute to the pathophysiology of different stress-related disorders, e.g. depression, with part...


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