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Effects of protein conformational transition accompanied with crosslinking dens...

Cai, Guolong; Zhao, Weikun; Zhu, Tianhao; Oliveira, Ana L.; Yao, Xiang; Zhang, Yaopeng

Silk fibroin (SF) hydrogels possess excellent biocompatibility and biomimetic properties of the extracellular matrix. Among them, the mild chemical crosslinked SF hydrogels show great application potential in the fields of 3D cell culture and tissue repairing and thus have attracted widespread attention. However, the mobility of hydrophobic chain segments of SF molecules in these chemical crosslinked hydrogels ...


Fiber diameters and parallel patterns: proliferation and osteogenesis of stem c...

Gu, Zhanghong; Fan, Suna; Kundu, Subhas C; Yao, Xiang; Zhang, Yaopeng

Due to the innate extracellular matrix mimicking features, fibrous materials exhibited great application potential in biomedicine. In developing excellent fibrous biomaterial, it is essential to reveal the corresponding inherent fiber featuresâ effects on cell behaviors. Due to the inevitable â interferenceâ cell adhesions to the background or between adjacent fibers, it is difficult to precisely reveal the inh...


Nonmulberry silk fibroin-based biomaterials: Impact on cell behavior regulation...

Zou, Shengzhi; Yao, Xiang; Shao, Huili; Reis, R. L.; Kundu, Subhas C; Zhang, Yaopeng

Silk fibroin (SF) is a promising biomaterial due to its good biocompatibility, easy availability, and high mechanical properties. Compared with mulberry silk fibroin (MSF), nonmulberry silk fibroin (NSF) isolated from typical nonmulberry silkworm silk exhibits unique arginine-glycine-aspartic acid (RGD) sequences with favorable cell adhesion enhancing effect. This inherent property probably makes the NSF more s...


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