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3D-MSCs A151 ODN-Loaded Exosomes Are Immunomodulatory And Reveal A Proteomic Ca...

P Camões, Sérgio; Bulut, Ozlem; Yazar, Volkan; Gaspar, Maria Manuela; Simões, Sandra; Ferreira, Rita; Vitorino, Rui; Santos, Jorge M.; Gursel, Ihsan

Introduction Non-healing wounds remain a major burden due to the lack of effective treatments. Mesenchymal stem cell-derived exosomes (MSC-Exo) have emerged as therapeutic options given their pro-regenerative and immunomodulatory features. Still, little is known on the exact mechanisms mediated by MSC-Exo. Importantly, modulation of their efficacy through 3D-physiologic cultures together with loading strategies...

Date: 2022   |   Origin: Repositório da Universidade de Lisboa
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