10 documents found, page 1 of 1
Identifying the Profile of Helicobacter pylori-Negative Gastric Cancers: A Case...
Morais, S; Peleteiro, B; Araújo, N; Malekzadeh, R; Ye, W; Plymoth, A; Tsugane, S; Hidaka, A; Hamada, GS; López-Carrillo, L; Zaridze, D; Maximovich, DBackground: The prevalence of Helicobacter pylori-negative gastric cancer (HpNGC) can be as low as 1%, when infection is assessed using more sensitive tests or considering the presence of gastric atrophy. HpNGC may share a high-risk profile contributing to the occurrence of cancer in the absence of infection. We estimated the proportion of HpNGC, using different criteria to define infection status, and compared...
Family History and Gastric Cancer Risk: A Pooled Investigation in the Stomach C...
Vitelli-Storelli, F; Rubín-García, M; Pelucchi, C; Benavente, Y; Bonzi, R; Rota, M; Palli, D; Ferraroni, M; Lunet, N; Morais, S; Ye, W; Plymoth, AAlthough there is a clear relationship between family history (FH) and the risk of gastric cancer (GC), quantification is still needed in relation to different histological types and anatomical sites, and in strata of covariates. The objective was to analyze the risk of GC according to first-degree FH in a uniquely large epidemiological consortium of GC. This investigation includes 5946 cases and 12,776 control...
Education and gastric cancer risk-An individual participant data meta-analysis ...
Rota, M; Alicandro, G; Pelucchi, C; Bonzi, R; Bertuccio, P; Hu, J; Zhang, ZF; Johnson, KC; Palli, D; Ferraroni, M; Yu, GP; Galeone, C; López-Carrillo, LLow socioeconomic position (SEP) is a strong risk factor for incidence and premature mortality from several cancers. Our study aimed at quantifying the association between SEP and gastric cancer (GC) risk through an individual participant data meta-analysis within the “Stomach cancer Pooling (StoP) Project”. Educational level and household income were used as proxies for the SEP. We estimated pooled odds ratios...
Sex differences in the prevalence of Helicobacter pylori infection: an individu...
Ferro, A; Morais, S; Pelucchi, C; Dierssen-Sotos, T; Martín, V; López-Carrillo, L; Malekzadeh, R; Tsugane, S; Hamada, GS; Hidaka, ABackground Helicobacter pylori (H. pylori) infection is more frequent among men, though the magnitude of the association might be inaccurate due to potential misclassification of lifetime infection and publication bias. Moreover, infection is common, and most studies are cross-sectional. Thus, prevalence ratios (PRs) may be easier to interpret than odds ratios (ORs). Aim The aim of this study was to quantify th...
Smoking and Helicobacter pylori infection: an individual participant pooled ana...
Ferro, A; Morais, S; Pelucchi, C; Aragonés, N; Kogevinas, M; López-Carrillo, L; Malekzadeh, R; Tsugane, S; Hamada, GS; Hidaka, A; Hernández-Ramírez, RUSmoking has been associated with acquisition and increased persistence of Helicobacter pylori infection, as well as with lower effectiveness of its eradication. A greater prevalence of infection among smokers could contribute to the increased risk for gastric cancer. We aimed to estimate the association between smoking and seropositivity to H. pylori through an individual participant data pooled analysis using ...
Tobacco smoking and gastric cancer: meta-analyses of published data versus pool...
Ferro, A; Morais, S; Rota, M; Pelucchi, C; Bertuccio, P; Bonzi, R; Galeone, C; Zhang, ZF; Matsuo, K; Ito, H; Hu, J; Johnson, KC; Yu, GP; Palli, DTobacco smoking is one of the main risk factors for gastric cancer, but the magnitude of the association estimated by conventional systematic reviews and meta-analyses might be inaccurate, due to heterogeneous reporting of data and publication bias. We aimed to quantify the combined impact of publication-related biases, and heterogeneity in data analysis or presentation, in the summary estimates obtained from c...
Alcohol intake and gastric cancer: Meta-analyses of published data versus indiv...
Ferro, A; Morais, S; Rota, M; Pelucchi, C; Bertuccio, P; Bonzi, R; Galeone, C; Zhang, ZF; Matsuo, K; Ito, H; Hu, J; Johnson, KC; Yu, GP; Palli, DBackground: Individual participant data pooled analyses allow access to non-published data and statistical reanalyses based on more homogeneous criteria than meta-analyses based on systematic reviews. We quantified the impact of publication-related biases and heterogeneity in data analysis and presentation in summary estimates of the association between alcohol drinking and gastric cancer. Methods: We compared ...
Analysis of (CAG) n Expansion in ATXN1, ATXN2 and ATXN3 in Chinese Patients Wit...
Zhou, X; Wang, C; Ding, D; Chen, Z; Peng, Y; Peng, H; Hou, X; Wang, P; Hou, X; Ye, W; Li, T; Yang, H; Qiu, R; Xia, K; Sequeiros, J; Tang, B; Jiang, HMultiple system atrophy (MSA) is a complex and multifactorial neurodegenerative disease, and its pathogenesis remains uncertain. Patients with MSA or spinocerebellar ataxia (SCA) show overlapping clinical phenotypes. Previous studies have reported that intermediate or long CAG expansions in SCA genes have been associated with other neurodegenerative disease. In this study, we screened for the number of CAG repe...
Alcohol consumption and gastric cancer risk - A pooled analysis within the StoP...
Rota, M; Pelucchi, C; Bertuccio, P; Matsuo, K; Zhang, ZF; Ito, H; Hu, J; Johnson, KC; Palli, D; Ferraroni, M; Yu, GP; Muscat, J; Lunet, N; Peleteiro, BAn association between heavy alcohol drinking and gastric cancer risk has been recently reported, but the issue is still open to discussion and quantification. We investigated the role of alcohol drinking on gastric cancer risk in the “Stomach cancer Pooling (StoP) Project,” a consortium of epidemiological studies. A total of 9,669 cases and 25,336 controls from 20 studies from Europe, Asia and North America we...
The stomach cancer pooling (StoP) project: study design and presentation
Pelucchi, C; Lunet, N; Boccia, S; Zhang, ZF; Praud, D; Boffetta, P; Levi, F; Matsu, K; Ito, H; Hu, J; Johnson, KC; Ferraroni, M; Yu, GP; Peleteiro, BGastric cancer affects about one million people per year worldwide, being the second leading cause of cancer mortality. The study of its etiology remains therefore a global issue as it may allow the identification of major targets, besides eradication of Helicobacter pylori infection, for primary prevention. It has however received little attention, given its comparatively low incidence in most high-income coun...