2 documents found, page 1 of 1
Epigenetic adaptations of the masticatory mucosa to periodontal inflammation
Richter, Gesa M; Kruppa, Jochen; Keceli, H Gencay; Ataman-Duruel, Emel Tuğba; Graetz, Christian; Pischon, Nicole; Wagner, Gunar; Rendenbach, CarstenBackground: In mucosal barrier interfaces, flexible responses of gene expression to long-term environmental changes allow adaptation and fine-tuning for the balance of host defense and uncontrolled not-resolving inflammation. Epigenetic modifications of the chromatin confer plasticity to the genetic information and give insight into how tissues use the genetic information to adapt to environmental factors. The ...
A combined epigenome- and transcriptome-wide association study of the oral mast...
Richter, Gesa M.; Kruppa, Jochen; Munz, Matthias; Wiehe, Ricarda; Häsler, Robert; Franke, Andre; Martins, Orlando; Jockel-Schneider, YvonneBackground: The oral mucosa has an important role in maintaining barrier integrity at the gateway to the gastrointestinal and respiratory tracts. Smoking is a strong environmental risk factor for the common oral inflammatory disease periodontitis and oral cancer. Cigarette smoke affects gene methylation and expression in various tissues. This is the first epigenome-wide association study (EWAS) that aimed to id...