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Animal models of depression and drug delivery with food as an effective dosing ...
Costa-Nunes, Joaõ P.; Cline, Brandon H.; Araújo-Correia, Margarida; Valencą, Andreia; Markova, Natalyia; Dolgov, Oleg; Kubatiev, Aslan; Yeritsyan, NairaMultiple models of human neuropsychiatric pathologies have been generated during the last decades which frequently use chronic dosing. Unfortunately, some drug administration methods may result in undesirable effects creating analysis confounds hampering model validity and preclinical assay outcomes. Here, automated analysis of floating behaviour, a sign of a depressive-like state, revealed that mice, subjected...
Date: 2015
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Origin: Repositório Institucional da UNL