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A secreted BMP antagonist, Cer1, fine tunes the spatial organization of the ure...

Chi, Lijun; Saarela, Ulla; Railo, Antti; Prunskaite-Hyyrylainen, Renata; Skovorodkin, Ilya; Anthony, Shelagh; Katsu, Kenjiro; Liu, Yu; Shan, Jingdong

The epithelial ureteric bud is critical for mammalian kidney development as it generates the ureter and the collecting duct system that induces nephrogenesis in dicrete locations in the kidney mesenchyme during its emergence. We show that a secreted Bmp antagonist Cerberus homologue (Cer1) fine tunes the organization of the ureteric tree during organogenesis in the mouse embryo. Both enhanced ureteric expressio...

Date: 2011   |   Origin: Sapientia - Universidade do Algarve
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