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Cyclo-(trp-phe) diketopiperazines from the endophytic fungus Aspergillus versic...
Gubiani,Juliana R.; Teles,Helder L.; Silva,Geraldo H.; Young,Maria Cláudia M.; Pereira,José O.; Bolzani,Vanderlan S.; Araujo,Angela R.Six known compounds, three peptide derivatives: cyclo-(tryptophyl-phenylalanyl) (2), diketopiperazine dimer WIN 64821 (3) and 3-hydroxy-15H-tryptophenaline (4), one adenine derivative: 2-hydroxy-6-N-isopentenyl-adenine (5), one phtalide derivative: 4-methoxyphtalide (1) and one benzoic acid derivative: 3-hydroxy-4-(1-hydroxy-1,5-dimethyl-hexyl) benzoic acid (6), were isolated from the ethyl acetate extract of t...
Antibacterial, antifungal and cytotoxic activities exhibited by endophytic fung...
Felício,Rafael de; Pavão,Gabriel B.; Oliveira,Ana Lígia L. de; Erbert,Cíntia; Conti,Raphael; Pupo,Monica T.; Furtado,Niege A.J.C.; Ferreira,Elthon G.Abstract Marine environment is one of the most important sources regarding natural products research. Besides, marine microorganisms have been denominated as a talented natural source for discovery of new leads. Although the association of macroalgae and fungi has been described regarding ecological issues, there is a lack of studies about marine seaweed endophytic fungi. In this context, the goal of this study...
Evaluation of acetylcholinesterase inhibitory activity of Brazilian red macroal...
Machado,Levi P.; Carvalho,Luciana R.; Young,Maria Cláudia M.; Cardoso-Lopes,Elaine M.; Centeno,Danilo C.; Zambotti-Villela,Leonardo; Colepicolo,PioAbstract Alzheimer's disease affects nearly 36.5 million people worldwide, and acetylcholinesterase inhibition is currently considered the main therapeutic strategy against it. Seaweed biodiversity in Brazil represents one of the most important sources of biologically active compounds for applications in phytotherapy. Accordingly, this study aimed to carry out a quantitative and qualitative assessment of Hypnea...
Sesquiterpenos produzidos pelo fungo endofítico Phomopsis cassiae com atividade...
Zanardi,Lisinéia M.; Bolzani,Vanderlan da S.; Cavalheiro,Alberto J.; Silva,Dulce H. Siqueira; Trevisan,Henrique C.; Araujo,Angela R.; Silva,Geraldo H.SESQUITERPENES PRODUCED BY ENDOPHYTIC FUNGUS Phomopsis cassiae WITH ANTIFUNGAL AND ACETYLCHOLINESTERASE INHIBITION ACTIVITIES. Two new diastereoisomeric cadinanes sesquiterpenes 3,9-dihydroxycalamenene (1-2), along with the known 3-hydroxycalamen-8-one (3) and aristelegone-A (4), were isolated from ethyl acetate extract of Phomopsis cassiae, an endophytic fungus in Cassia spectabilis. Their structures, includin...
Chemical composition and acetylcholinesterase inhibitory activity of essential ...
Souza,Amanda de; Lopes,Elaine M. Cardoso; Silva,Michelle C. da; Cordeiro,Inês; Young,Maria Cláudia M.; Sobral,Marcos E. G.; Moreno,Paulo R. H.The chemical composition of volatile oils from two Myrtaceae species, Myrceugenia myrcioidesand Eugenia riedeliana, both native from the Brazilian Atlantic Rain Forest, was analyzed by GC-MS. Acetylcholinesterase inhibitory activity was colorimetrically evaluated for these oils. For M. myrcioides, monoterpene hydrocarbons represented the major class in the volatile oil, with α-pinene as the most abundant compon...
Indole monoterpene alkaloids from Chimarrhis turbinata DC Prodr.: a contributio...
Cardoso,Carmen L.; Silva,Dulce Helena S.; Young,Maria Cláudia M.; Castro-Gamboa,Ian; Bolzani,Vanderlan da SilvaThe morphological parameters used to establish close connections among species taxonomically different into the Rubiaceae family is complex, mainly due to the lack of information on habitat and morphoanatomical characters in the lower hierarchic groups, for example, Chimarrhis genus. The micromolecular profile of delimited species into determined taxa can be useful to establish the boundaries among close taxono...
Substâncias antifúngicas de Xylaria sp., um fungo endofítico isolado de Palicou...
Cafêu,Mariana C.; Silva,Geraldo H.; Teles,Helder L.; Bolzani,Vanderlan da S.; Araújo,Ângela R.; Young,Maria Cláudia M.; Pfenning,Ludwig H.Five compounds, 2-hexyl-3-methyl-butanodioic acid (1), cytochalasin D (2), 7-dechlorogriseofulvin (3), cytochalasin B (4) and griseofulvin (5), have been isolated from the endophytic fungus Xylaria sp., and their structures were elucidated on the basis of spectroscopic data. In the bioautography assay against Cladosporium cladosporioides and Cladosporium sphaerospermum, compounds 1 and 2 were found to be active...
Flavonoids from Chiococca braquiata (Rubiaceae)
Lopes,Marcia N.; Oliveira,André C. de; Young,Maria Cláudia M.; Bolzani,Vanderlan da S.A new flavonol 4'-methoxykaempferol-7-(acetyloxy)-3,5-O-alpha-L-rhamnoside (1), was isolated from the leaves of Chiococca braquiata, along with three known flavonoids apigenin, 7-O-methoxyquercetrin and quercetrin and four triterpenes alpha-amirin, beta-amirin, ursolic and oleanolic acids . Their structures were established on the basis of spectroscopic methods.