12 documents found, page 1 of 2
Ageing affects the CD4+ T cell polarization and mucosal tropism induced by TLR2...
Zúquete, Sara; Ferreira, Mariana; Delgado, Inês L.; Rosa, Maria teresa; Mendes, Ana Catarina; Santos, Dulce; Nolasco, Sofia; Graça, LuísToll-like receptor (TLR)2 activation induces aldehyde dehydrogenase enzymes in non-mucosal dendritic cells (DCs), enabling them to metabolize vitamin A into all-trans retinoic acid, which induces the expression of mucosal-homing molecules (α4β7 and CCR9) in the activated T cells. Recently, we have shown that the simultaneous activation of non-mucosal DCs through TLR2 and TLR4 maintains such capacity while reinf...
Balancing act: tubulin glutamylation and microtubule dynamics in Toxoplasma gondii
Delgado, Inês; Gonçalves, João; Fernandes, Rita; Zúquete, Sara; Basto, Afonso P.; Leitão, Alexandre; Soares, Helena; Nolasco, SofiaThe success of the intracellular parasite Toxoplasma gondii in invading host cells relies on the apical complex, a specialized microtubule cytoskeleton structure associated with secretory organelles. The T. gondii genome encodes three isoforms of both α- and β-tubulin, which undergo specific post-translational modifications (PTMs), altering the biochemical and biophysical proprieties of microtubules and modulat...
Balancing act: tubulin glutamylation and microtubule dynamics in Toxoplasma gondii
Delgado, Inês L.S.; Gonçalves, João; Fernandes, Rita; Zúquete, Sara; Basto, Afonso P.; Leitão, Alexandre; Soares, Helena; Nolasco, SofiaThe success of Toxoplasma gondii (intracellular parasite) host cell invasion relies on the apical complex, a specialized microtubule cytoskeleton structure associated with secretory organelles. The genome encodes three isoforms of both α- and β-tubulin which are altered by specific post-translational modifications (PTMs), changing the biochemical/biophysical proprieties of microtubules, and modulating their int...
Combined TLR2/TLR4 activation equip non-mucosal dendritic cells to prime Th1 ce...
Zúquete, Sara; Ferreira, Mariana; Delgado, Inês L. S.; Gazalle, Paula; Andaluz, Stephanie; Rosa, Maria Teresa; Mendes, Ana Catarina; Santos, DulceActivated CD4+ T cells located at mucosal surfaces orchestrate local effector immune mechanisms. When properly polarized, these cells contribute to block infections at early stages and may be essential to restrain the local growth of mucosal tumors, playing a critical role in host protection. How CD4+ T cells simultaneously integrate gut-homing instructions and Th polarization signals transmitted by TLR-activat...
Tick-borne diseases in asymptomatic cattle from São Miguel Island, Azores – A c...
Felício, Maria; Zúquete, Sara; Lima, Patrícia; Delgado, Inês; Reis, Pedro; Romão, Ricardo; Nolasco, Sofia; Santos, Dulce; Basto, Afonso; Padre, LudovinaTick-borne diseases in asymptomatic cattle from São Miguel Island, Azores – A clinical perspective Introduction/Background: The Azores archipelago is one of the regions with the highest cattle production, in Portugal. Outbreaks of tick-borne (TB) diseases have been reported by local field veterinarians and different tick species are described in São Miguel. At this study, we decided to investigate the presence ...
The apicomplexan parasite Toxoplasma gondii
Delgado, Inês; Zúquete, Sara; Santos, Dulce; Basto, Afonso Silva Pinto; Leitão, José Alexandre da Costa Perdigão e Cameira; Nolasco, SofiaToxoplasma gondii is a ubiquitous zoonotic parasite with an obligatory intracellular lifestyle. It relies on a specialized set of cytoskeletal and secretory organelles for host cell invasion. When infecting its felid definitive host, T. gondii undergoes sexual reproduction in the intestinal epithelium, producing oocysts that are excreted with the feces and sporulate in the environment. In other hosts and/or tis...
The apicomplexan parasite Toxoplasma gondii
Delgado, Inês L. S.; Zúquete, Sara; Santos, Dulce; Basto, Afonso P.; Leitão, Alexandre; Nolasco, SofiaToxoplasma gondii is a ubiquitous zoonotic parasite with an obligatory intracellular lifestyle. It relies on a specialized set of cytoskeletal and secretory organelles for host cell invasion. When infecting its felid definitive host, T. gondii undergoes sexual reproduction in the intestinal epithelium, producing oocysts that are excreted with the feces and sporulate in the environment. In other hosts and/or tis...
Impact of endemic Besnoitiosis on the performance of a dairy cattle herd
Anastácio, Catarina; Bexiga, Ricardo; Nolasco, Sofia; Zúquete, Sara; Delgado, Inês L. S.; Nunes, Telmo; Leitão, AlexandreThis study aimed to assess the effect of Besnoitia besnoiti infection on the reproductive and productive performance of a dairy cattle herd. A serological screening was performed by indirect fluorescent antibody test (IFAT) on every animal aged over one year (n = 262). Subsequently, 211 animals were clinically examined, with 96 of those being screened for detection of sclerocysts. The overall seroprevalence was...
Characterization of a MOB1 homolog in the Apicomplexan parasite toxoplasma gondii
Delgado, Inês L. S.; Tavares, Alexandra; Francisco, Samuel; Santos, Dulce; Coelho, João; Basto, Afonso P.; Zúquete, Sara; Müller, JoachimMonopolar spindle One Binder1 (MOB1) proteins are conserved components of the tumor-suppressing Hippo pathway, regulating cellular processes such as cytokinesis. Apicomplexan parasites present a life cycle that relies on the parasites’ ability to differentiate between stages and regulate their proliferation; thus, Hippo signaling pathways could play an important role in the regulation of the apicomplexan life c...
Em Portugal, Fasciola hepatica, Fasciola gigantica ou hibridos? Um estudo morfo...
Martins, Liliana; Zúquete, Sara; Vilhena, Manuela; Padre, LudovinaEm Portugal, Fasciola hepatica, Fasciola gigantica ou hibridos? Um estudo morfométrico Martins, L.C.A, Zuquete.S., Vilhena M. M.C., Padre L., Padre L.: lpadre@uevora.pt Introdução: A diferenciação e identificação das populações de Fasciola hepaticaXFasciola gigantica é importante no controlo da doença, tendo em conta as diferentes características de transmissão, epidemiologia e patologia. Objetivos: Estudar a m...