5 documents found, page 1 of 1
Multiparametric in vitro genotoxicity assessment of different variants of amorp...
Brandão, Fátima; Costa, Carla; Bessa, Maria João; Valdiglesias, Vanessa; Hellack, Bryan; Haase, Andrea; Fraga, Sónia; Teixeira, João PauloThe hazard posed to human health by inhaled amorphous silica nanomaterials (aSiO2 NM) remains uncertain. Herein, we assessed the cyto- and genotoxicity of aSiO2 NM variants covering different sizes (7, 15, and 40 nm) and surface modifications (unmodified, phosphonate-, amino- and trimethylsilyl-modified) on rat alveolar epithelial (RLE-6TN) cells. Cytotoxicity was evaluated at 24 h after exposure to the aSiO2 N...
Genotoxicity and Gene Expression in the Rat Lung Tissue following Instillation ...
Brandão, Fátima; Costa, Carla; Bessa, Maria João; Dumortier, Elise; Debacq-Chainiaux, Florence; Hubaux, Roland; Salmon, Michel; Laloy, JulieSeveral reports on amorphous silica nanomaterial (aSiO2 NM) toxicity have been questioning their safety. Herein, we investigated the in vivo pulmonary toxicity of four variants of aSiO2 NM: SiO2_15_Unmod, SiO2_15_Amino, SiO2_7 and SiO2_40. We focused on alterations in lung DNA and protein integrity, and gene expression following single intratracheal instillation in rats. Additionally, a short-term inhalation st...
Toxicity of different classes of manufactured nanomaterials in rat alveolar epi...
Brandão, Fátima; Fraga, Sónia; Costa, Carla; Silva, Susana; Bessa, Maria João; Haase, Andrea; Teixeira, João PauloThe rapid development of manufactured nanomaterials (MNMs) and their increased use for commercial and industrial applications lead to the urgent need of the toxicological assessment of their potential toxicity. Thus, this study evaluated the cyto- and genotoxicity of a panel of MNMs, including SiO2 nanoparticles (NPs), graphene oxide and nano-sized pigments in rat alveolar epithelial cells (RLE-6TN), a primary ...
Cytotoxicity and DNA damage of a panel of manufactured nanomaterials in rat alv...
Brandão, Fátima; Fraga, Sónia; Costa, Carla; Bessa, Maria João; Haase, Andrea; Teixeira, João PauloMain goal: The aim of this study was to evaluate the cyto- and genotoxicity of a panel of MNMs, including SiO2 NPs, graphene oxide, and nano-sized pigments in rat alveolar epithelial cells (RLE-6TN), a primary target following inhalation exposure.
Toxicity of different classes of manufactured naomaterials in alveolar epitheli...
Brandão, Fátima; Fraga, Sónia; Costa, Carla; Bessa, Maria João; Haase, Andrea; Teixeira, João PauloThe toxicological assessment of the potential toxicity of manufactured nanomaterials (MNMs) is urgently needed due to their increased use for commercial and industrial applications. Thus, this study evaluated the cyto- and genotoxicity of a panel of MNMs, including SiO2 NPs, graphene oxide, and nano-sized pigments in rat alveolar epithelial cells (RLE-6TN), a primary target during inhalation exposure.