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In vitro and in vivo assessment of nanoceria biocompatibility for their safe us...

Fernández-Bertólez, N; Martínez, L; Ramos-Pan, L; Touzani, A; Costa, C; Laffon, B; Valdiglesias, V

Nanoceria, or cerium dioxide nanoparticles (CeO2 NP), are increasingly employed in a number of industrial and commercial applications. Hence, the environmental presence of these nanoparticles is growing progressively, enhancing the global concern on their potential health effects. Recent studies suggest that nanoceria may also have promising biomedical applications particularly in neurodegenerative and brain-re...


Toxicity of zinc oxide nanoparticles: Cellular and behavioural effects

Fernández-Bertólez, N; Alba-González, A; Touzani, A; Ramos-Pan, L; Méndez, J; Reis, AT; Quelle-Regaldie, A; Sánchez, L; Folgueira, M; Laffon, B

Due to their extensive use, the release of zinc oxide nanoparticles (ZnO NP) into the environment is increasing and may lead to unintended risk to both human health and ecosystems. Access of ZnO NP to the brain has been demonstrated, so their potential toxicity on the nervous system is a matter of particular concern. Although evaluation of ZnO NP toxicity has been reported in several previous studies, the speci...


Impact of gold nanoparticle exposure on genetic material

Ramos-Pan, L; Touzani, A; Fernández-Bertólez, N; Fraga, S; Laffon, B; Valdiglesias, V

Metal nanoparticles, with gold nanoparticles (AuNP) at the forefront, have gained immense attention due to their unique properties. At the nanoscale, gold exhibits remarkable physical, chemical, optical, and electronic features, making it ideal for a plethora of applications, including bioimaging, sensing, diagnostics, and drug delivery. Despite their promising utility, concerns have arisen regarding the potent...


Effects of Zinc Oxide Nanoparticle Exposure on Human Glial Cells and Zebrafish ...

Valdiglesias, V; Alba-González, A; Fernández-Bertólez, N; Touzani, A; Ramos-Pan, L; Reis, AT; Moreda-Piñeiro, J; Yáñez, J; Laffon, B; Folgueira, M

Zinc oxide nanoparticles (ZnO NPs) are among the most widely used nanomaterials. They have multiple applications in cosmetics, textiles, paints, electronics and, recently, also in biomedicine. This extensive use of ZnO NPs notably increases the probability that both humans and wildlife are subjected to undesirable effects. Despite being among the most studied NPs from a toxicological point of view, much remains...


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