2 documents found, page 1 of 1
Bone marrow fibrosis at diagnosis is associated with TP53 overexpression and ad...
Duarte, Fernando B.; Barbosa, Maritza C.; Santos, Talyta E. Jesus dos; Lemes, Romélia Pinheiro Gonçalves; Vasconcelos, João P.Myelodysplastic syndrome (MDS) is a heterogeneous group of stem cell clonal alterations, culminating in a high risk of progression to acute myeloid leukaemia (AML) (Greenberg et al, 2012). The prognosis of these patients is commonly determined by the International Prognostic Score System (IPSS), which considers the number of cytopenias, cytogenetic alterations and number of blasts in the bone marrow at diagnosi...
Presence of new mutations in the TP53 gene in patients with low-risk myelodyspl...
Duarte, Fernando Barroso; Lemes, Romélia Pinheiro Gonçalves; Santos, Talyta Ellen de Jesus dos; Barbosa, Maritza CavalcanteBackground Myelodysplastic syndromes are heterogeneous disorders. Patients with myelodysplastic syndrome disease often have ineffective hematopoiesis, cytopenias, blood cell dysplasia in one or more cell types, and are at high risk for developing acute myeloid leukemia. In myelodysplastic syndrome, mutations of TP53 gene are usually associated with complex karyotype and confer a worse prognosis. In the present ...