4 documents found, page 1 of 1
Gasdermin D inhibition prevents multiple organ dysfunction during sepsis by blo...
Silva, Camila Meirelles S.; Wanderley, Carlos Wagner S.; Veras, Flavio P.; Sonego, Fabiane; Nascimento, Daniele C.; Gonçalves, Augusto V.Made available in DSpace on 2022-04-29T08:46:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-12-23; Multiple organ dysfunction is the most severe outcome of sepsis progression and is highly correlated with a worse prognosis. Excessive neutrophil extracellular traps (NETs) are critical players in the development of organ failure during sepsis. Therefore, interventions targeting NET release would likely...
Relevance of the Myeloid Differentiation Factor 88 (MyD88) on RANKL, OPG, and N...
Leite, Fábio Renato Manzolli [UNESP]; de Aquino, Sabrina Garcia [UNESP]; Guimarães, Morgana Rodrigues [UNESP]; Cirelli, Joni Augusto [UNESP]Made available in DSpace on 2021-06-25T10:32:46Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-02-01; The myeloid differentiation factor 88 (MyD88) plays a pivotal role in Toll-like receptor (TLR)- and interleukin-1 receptor (IL-1R)-induced osteoclastogenesis. We examined the role of MyD88 on p38 mitogen-activated protein kinase (MAPK) and nuclear factor kappa-light-chain-enhancer of activated B cell (N...
Mitochondrial DNA activates the nlrP3 inflammasome and predisposes to Type 1 di...
Carlos, Daniela; Costa, Frederico R. C.; Pereira, Camila A.; Rocha, Fernanda A.; Yaochite, Juliana N. U.; Oliveira, Gabriela G.; Carneiro, Fernando S.Although a correlation between polymorphisms of NOD-like receptor family-pyrin domain containing 3 (NLRP3) and predisposition to type 1 diabetes (T1D) has been identified, the potential function and activation of the NLRP3 inflammasome in T1D have not been clarified. The present study shows that non-obese diabetic mice exhibited increased NLRP3, and pro-IL-1β gene expression in pancreatic lymph nodes (PLNs). Si...
Role of NOD2 and RIP2 in host-microbe interactions with Gram-negative bacteria:...
Souza, Joao A.C. [UNESP]; Medeiros, Marcell C. [UNESP]; Rocha, Fernanda R.G. [UNESP]; De Aquino, Sabrina G. [UNESP]; Ávila-Campos, Mario J.Made available in DSpace on 2018-12-11T17:07:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-11-01; National Institute of Dental and Craniofacial Research; NOD2 is a member of the NLR family of proteins that participate in the activation of the innate immune response. RIP2 is a downstream kinase activated by both NOD1 and NOD2. There is scarcity of information regarding the relevance of NOD2 in period...