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Performance of recombinant chimeric proteins in the serological diagnosis of Tr...
Leony, Leonardo Maia; Freitas, Natália Erdens Maron de; Del-Rei, Rodrigo Pimenta; Carneiro, Cláudia Martins; Reis, Alexandre Barbosa; Jansen, Ana MariaBackground: Dogs are considered sentinels in areas of Trypanosoma cruzi transmission risk to humans. ELISA is generally the method of choice for diagnosing T. cruzi exposure in dogs, but its performance substantially depends on the antigenic matrix employed. In previous studies, our group has developed four chimeric antigens (IBMP-8.1, 8.2, 8.3, and 8.4) and evaluated their potential for diagnosing T. cruzi exp...
PI3K inhibition synergizes with glucocorticoids but antagonizes with methotrexa...
Silveira, André Bortolini; Laranjeira, Angelo Brunelli Albertoni; Rodrigues, Gisele Olinto Libanio; Leal, Paulo César; Cardoso, Bruno A.The PI3K pathway is frequently hyperactivated in primary T-cell acute lymphoblastic leukemia (T-ALL) cells. Activation of the PI3K pathway has been suggested as one mechanism of glucocorticoid resistance in T-ALL, and patients harboring mutations in the PI3K negative regulator PTEN may be at increased risk of induction failure and relapse. By gene expression microarray analysis of T-ALL cells treated with the P...
The human nucleolar protein FTSJ3 associates with NIP7 and functions in pre-rRN...
Zanchin, Nilson Ivo Tonin