2 documents found, page 1 of 1
AKT can modulate the in vitro response of HNSCC cells to irreversible EGFR inhi...
Silva-Oliveira, Renato José; Melendez, Matias; Martinho, Olga; Zanon, Maicon F.; Viana, Luciano de Souza; Carvalho, André Lopes; Reis, R. M.Epidermal growth factor receptor (EGFR) is overexpressed in up to 90% of head and neck squamous cell carcinoma (HNSCC) tumors. Cetuximab is the first targeted (anti-EGFR) therapy approved for the treatment of HNSCC patients. However, its efficacy is limited due to primary and secondary resistance, and there is no predict biomarkers of response. New generation of EGFR inhibitors with pan HER targeting and irreve...
Detection of ALK fusion transcripts in FFPE lung cancer samples by NanoString t...
Evangelista, Adriane F.; Zanon, Maicon F.; Carloni, Adriana C.; Paula, Flávia Escremim de; Morini, Mariana Andozia; Ferreira-Neto, MaressaBackground: ALK-rearranged lung cancers exhibit specific pathologic and clinical features and are responsive to anti-ALK therapies. Therefore, the detection of ALK-rearrangement is fundamental for personalized lung cancer therapy. Recently, new molecular techniques, such as NanoString nCounter, have been developed to detect ALK fusions with more accuracy and sensitivity. Methods: In the present study, we intend...